Korean J Urol.  1998 May;39(5):454-458.

Proliferation and Apoptosis in Prostatic Hypertrophy

• Choi HR
• Koo HS

Abstract

PURPOSE: Volumetric change of prostate is the result of unbalanced proliferation and apoptosis. We investigated the characteristics of proliferation and apoptosis in hypertrophic prostate.
MATERIALS AND METHODS
Proliferative and apoptotic rates were quantitated with immunoprofiles of proliferative cell nuclear antigen(PCNA) and apoptotic body with 46 paraffin-embeded BPH specimen. When the rate of proliferation was higher than that of apoptosis, we defined as proliferation active group.
RESULTS
Proliferation and apoptotic rates of stromal and epithelial cells were 4.5%, 2.9% and 1.9%, 1.1%, respectively(p<0.05). There was modest correlation between stromal volume and the proliferation rate of stromal cells(p<0.05, R=0.3209). There was no volumetric difference in the prostate between proliferation active and inactive group(p> 0.05).
CONCLUSIONS
These results demonstrate that stromal proliferation is the main cause of prostatic hypertrophy. The unbalance between proliferation and apoptosis of prostatic cells seems to be unsteady in time.

Keyword

Benign prostatic hyperplasia; Proliferation; Apoptosis

MeSH Terms

Apoptosis*
Epithelial Cells
Prostate
Prostatic Hyperplasia*