Prostatic core biopsy in benign prostatic hypertrophy for the estimation of histologic ratio

Hong, Sung Joon; Ahn, Hyun Soo

Abstract

To investigate whether the prostatic biopsy specimen can be used for the estimation of total prostatic histologic ratio or not. we compared the relative volume density of glandular lumen from the open prostatectomy specimens with the relative area density of glandular lumen from the biopsied specimens in five patients with benign prostatic hypertrophy. We took four core biopsy specimens from each prostate. The overall correlation coefficiencies between volume densities and area densilies of each one to four combinations were 0.795, 0.898. 0.941 and 0.965 respectively. Furthermore. the probabilities of obtaining statistically significant values from each of one to four biopsy combinations were 50%, 65%, 100% and l00% respectively. In conclusion, the random biopsy specimens taken from more than three different sites would be enough to get the precise and reliable information about the histologic content of prostate.