Korean J Blood Transfus.
2005 Jun;16(1):20-31.
The Frequency and Clinical Significance of Delayed Serological Transfusion Reactions in Korean Population
- Affiliations
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- 1Departments of Laboratory Medicine, College of Medicine, Pusan National University, Busan, Korea. hhkim@pusan.ac.kr
- 2Departments of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea.
- 3Department of Medical Informatics, School of Medicine, Kyungpook National University, Taegu, Korea.
Abstract
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BACKGROUND: Alloantibodies to red cell antigens may cause acute or delayed hemolytic transfusion reactions (DHTRs). In most cases, however, anamnestic antibody production causes only a delayed serological transfusion reaction (DSTR). According to the previous reports, alloimmunization occured with a risk of 1-2.6%, however, no prospective studies on a DSTR have been performed in Korea. The purpose of this study was to evaluate prospectively the frequency of alloimmunization and its clinical significance in Korean population.
METHODS
Antibody screening tests were performed for a total of 1,903 patients who were transfused with packed RBCs from May 2003 through July 2004. One blood sample from each patient was collected within 7-10 day after transfusion and screened for serological evidence of alloimmunization. If any antibody was detected the patient's post-transfusion sample was screened for biochemical evidence of hemolysis and the patients' medical records were reviewed for documentation of clinical signs of a transfusion reaction.
RESULTS
Overall, 17/1,903 patients became alloimmunized for a frequency of 0.89%. Only one of 1,903 patients had clinical evidence of hemolysis, and the frequency of DHTR was 0.053%. Interestingly, anti-Dia which was characteristic antibody in Asian-Mongoloid populations was detected in three patients, and anti-Mia was found in one patient.
CONCLUSION
This study showed lower frequency of DSTR and DHTR, compared with previous studies in Caucasian. However, it is noteworthy that the incidence of anti-Dia was relatively higher in Korean population.
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