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Treatment Patterns of Type 2 Diabetes Assessed Using a Common Data Model Based on Electronic Health Records of 2000–2019

Lee KA, Jin HY, Kim YJ, Im YJ, Kim EY, Park TS

Background: Real-world data analysis is useful for identifying treatment patterns. Understanding drug prescription patterns of type 2 diabetes mellitus may facilitate diabetes management. We aimed to analyze treatment patterns of type...
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Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease

Song JH, Kim GT, Park KH, Park WJ, Park TS

  • KMID: 2517155
  • Biomol Ther.
  • 2021 Jul;29(4):373-383.
Atherosclerosis is the deposition of plaque in the main arteries. It is an inflammatory condition involving the accumulation of macrophages and various lipids (low-density lipoprotein [LDL] cholesterol, ceramide, S1P). Moreover,...
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Risk of Coronavirus Disease 2019 Occurrence, Severe Presentation, and Mortality in Patients with Lung Cancer

Yang B, Choi H, Lee SK, Chung SJ, Yeo Y, Shin YM, Park DW, Park TS, Moon JY, Kim TH, Sim YS, Yoon HJ, Sohn JW, Lee H, Kim SH

Purpose This study aimed to analyze whether patients with lung cancer have a higher susceptibility of coronavirus disease 2019 (COVID-19), severe presentation, and higher mortality than those without lung cancer. Materials...
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Erratum to “Utilization of pain and sedation therapy on noninvasive mechanical ventilation in Korean intensive care units: a multi-center prospective observational study”

Kim T, Kim JS, Choi EY, Chang Y, Choi WI, Hwang JJ, Moon JY, Lee K, Kim SW, Kang HK, Sim YS, Park TS, Park SY, Park S, Cho JH, on behalf of the Korean NIV Study Group

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Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015) (Diabetes Metab J 2021;45:115-9)

Moon SS, Kim CH, Kang SM, Kim ES, Oh TJ, Yun JS, Cho HC, Kim DJ, Park TS

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Clinical outcomes of endovascular treatment for ruptured thoracic aortic disease

Choi JH, Kim SP, Lee HC, Park TS, Park JH, Kim BW, Ahn J, Park JS, Lee HW, Oh JH, Choi JH, Cha KS, Hong TJ

Background/Aims: Untreated rupture of the thoracic aorta is associated with a high mortality rate. We aimed to review the clinical results of endovascular treatment for ruptured thoracic aortic disease. Methods: We...
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Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats (Diabetes Metab J 2020;44:842-53)

Kim SH, Park TS, Jin HY

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Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015)

Moon SS, Kim CH, Kang SM, Kim ES, Oh TJ, Yun JS, Cho HC, Kim DJ, Park TS

This report presents the status of diabetic neuropathy (DN) in Korea as determined using a National Health Insurance ServiceNational Sample Cohort (NHIS-NSC). Annual prevalences of DN were estimated by age...
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Lactobacillus attenuates progression of nonalcoholic fatty liver disease by lowering cholesterol and steatosis

Lee NY, Shin MJ, Youn GS, Yoon SJ, Choi YR, Kim HS, Gupta H, Han SH, Kim BK, Lee DY, Park TS, Sung H, Kim BY, Suk KT

Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is closely related to gut-microbiome. There is a paucity of research on which strains of gut microbiota affect the progression of NAFLD. This study...
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Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy

Woo CY, Baek JY, Kim AR, Hong CH, Yoon JE, Kim HS, Yoo HJ, Park TS, Kc R, Lee KU, Koh EH

BackgroundCeramides are associated with metabolic complications including diabetic nephropathy in patients with diabetes. Recent studies have reported that podocytes play a pivotal role in the progression of diabetic nephropathy. Also,...
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γ-Linolenic Acid versus α-Lipoic Acid for Treating Painful Diabetic Neuropathy in Adults: A 12-Week, Double-Placebo, Randomized, Noninferiority Trial

Won JC, Kwon HS, Moon SS, Chun SW, Kim CH, Park IB, Kim IJ, Lee J, Cha BY, Park TS

BackgroundThis study was a multicenter, parallel-group, double-blind, double-dummy, randomized, noninferiority trial to evaluate the efficacy and safety of γ-linolenic acid (GLA) relative to α-lipoic acid (ALA) over a 12-week treatment period in...
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Therapeutic potential of stem cell-derived extracellular vesicles in osteoarthritis: preclinical study findings

Kim KH, Jo JH, Cho HJ, Park TS, Kim TM

Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeutic purposes, stem cell-derived...
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Hepatic Expression of the Serine Palmitoyltransferase Subunit Sptlc2 Reduces Lipid Droplets in the Liver by Activating VLDL Secretion

Kim GT, Kim SJ, Park SH, Lee D, Park TS

Objective: Ceramide is a signaling molecule that contributes to insulin resistance and hepatosteatosis. In the present study, we activated de novo ceramide synthesis by inducing the hepatic expression of Sptlc2...
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Gradual Increase in Hematologic Malignancy in Korea from 2005 to 2015 Based on the National Health Insurance Service Data

Han Y, Kim YJ, Kim MJ, Byun JM, Youk T, Yoon HS, Lee JH, Lee WI, Park TS, Yoo J

Background Hematologic malignancies have a relatively lower prevalence than major solid cancers, although the incidence of hematologic malignancies has significantly increased in recent years. However, understanding the current status of hematologic...
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Attachment distribution of pectoral muscle origins identified in dual-plane breast implant insertion

Nam SB, Song KH, Seo JY, Choi JS, Park TS, Lee JW, Kim JH, Kim MW, Kim HY, Jung YJ, Kim C

Background Implant-based dual-plane augmentation mammoplasty requires accurate separation of the pectoralis major muscle (PMM) at its origins. The authors identified the PMM origins during breast reconstruction surgery with the goal...
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Volumetric change of the latissimus dorsi muscle after postoperative radiotherapy in immediate breast reconstruction with an extended latissimus dorsi musculocutaneous flap

Park TS, Seo JY, Razzokov A, Choi JS, Kim MW, Lee JW, Kim HY, Jung YJ, Choo KS, Song KH, Nam SB

Background This study aimed to determine the magnitude of volume reduction of the latissimus dorsi (LD) muscle after treatment using only postoperative radiotherapy (PORTx) in patients who underwent immediate breast...
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Reference Ranges of Serum Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3: Results from a Multicenter Study in Healthy Korean Adults

Jeong IK, Byun JK, Noh J, Kim SW, Chung YS, Park TS, Kim SW

Insulin-like growth factor-I (IGF-I) plays a pivotal role in the diagnosis and treatment of growth hormone (GH) excess or deficiency. The GH study group of the Korean Endocrine Society aims...
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Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats

Kim SH, Park TS, Jin HY

Background Metformin is widely marketed medication for the treatment of diabetes, but its pharmacological effect on diabetic peripheral neuropathy remains unclear. In this study, the effect of metformin on peripheral nerves...
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Utilization of pain and sedation therapy on noninvasive mechanical ventilation in Korean intensive care units: a multi-center prospective observational study

Kim T, Kim JS, Choi EY, Chang Y, Choi WI, Hwang JJ, Moon JY, Lee K, Kim SW, Kang HK, Sim YS, Park TS, Park SY, Park S, Cho JH, on behalf of the Korean NIV Study Group

Background: The use of sedative drugs may be an important therapeutic intervention during noninvasive ventilation (NIV) in intensive care units (ICUs). The purpose of this study was to assess the...
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Epidemiology of Congenital Bleeding Disorders: a Nationwide Populationbased Korean Study

Yoon HS, Han Y, Kim YJ, Kim MJ, Byun JM, Youk T, Lee JH, Park TS, Yoo J

Background: Except for data in the Korea Hemophilia Foundation Registry, little is known of the epidemiology of congenital bleeding disorders in Korea. Methods: Data were obtained from the Korean Health Insurance...
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