Korean J Anesthesiol.  1996 Apr;30(4):419-425. 10.4097/kjae.1996.30.4.419.

The Effects of Atropine and Glycopyrrolate on the Recovery from Mivacurium: Induced Neuromuscular Blockade in the Rabbit

• Kwon OK
• Kim CS

• KMID: 1860463
• DOI: http://doi.org/10.4097/kjae.1996.30.4.419

Abstract

BACKGROUND: Antimuscarinic agents are used to block undesirable muscarinic effects of `anticholinesterase given to reverse the residual neuromuscular blockade produced by muscle relaxants. However, besides antimuscarinic effects, atropine was known to have some positive effects on the recovery from neuromuscular blockade by acting at the presynaptic muscarinic receptor of the neuromuscular junction. But there have been few reports about the neuromuscular effects of glycopyrrolate. So we observed the neuromuscular effects of atropine and glycopyrrolate, and compared two.
METHODS
Mivacurium(0.064 mg/kg) was administered intravenously and the experimental groups were divided into 5 groups: the control group (no antimuscarinic agent administered), Al group (0.02 mg/kg atropine administered), A2 group (0.04 m atropine administered), Gl group (0.01 mg/kg glycopyrrolate administered) and G2 group (0.02 mg/kg glycopyrrolate administered). The left cammon peroneal nerve was stimulated by the 0.1 Hz single twitch and 100 Hz tetanic stimuli. We manitored the mechanical activity of the anterior tibialis muscle and observed recovery index, tetanic fade, and post-tetanic potentiation.
RESULTS
There were no significant differences in recovery indices and post-tetanic potentiations among the 5 groups. Significant differences were found in tetanic fades between the experimental groups(A1, A2, Gl, G2) and the control group(P<0.05). However no significant differences in tetanic fades were found among the experimental groups.
CONCLUSIONS
Atropine and glycopyrrolate hastened the recovery from mivacurium induced neuromuscular blockade. The neuromuscular recovery effects of glycopyrmlate were found to be similar to atropine at equipotent dose.

Keyword

Neuromuscular relaxants; recovery; mivacurium; Parasympathetic nervous system; atropine; glycopyrrolate

MeSH Terms

Atropine*
Cholinergic Agents
Glycopyrrolate*
Muscarinic Antagonists
Neuromuscular Agents
Neuromuscular Blockade*
Neuromuscular Junction
Parasympathetic Nervous System
Peroneal Nerve
Receptors, Muscarinic
Refractory Period, Electrophysiological
Atropine
Cholinergic Agents
Glycopyrrolate
Muscarinic Antagonists
Neuromuscular Agents
Receptors, Muscarinic