- Prejunctional Phenomenon during Succinylcholine Onset in Cats
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Yoon KB, Choi JC, Chae YJ, Han JW, Chang HS, Kim SY
- KMID: 2237535
- Korean J Anesthesiol.
- 2004 Aug;47(2):238-241.
- doi: 10.4097/kjae.2004.47.2.238
BACKGROUND: Succinylcholine (Sch) has been generally reported not to produce tetanic stimulation fade on train of four in phase I block, except phase II block. But, the prejunctional phenomenon of... -
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- At therapeutic concentration bupivacaine causes neuromuscular blockade and enhances rocuronium-induced blockade
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Lee JH, Lee SI, Lee SC, Choi SR, Rhee WJ
- KMID: 2243827
- Korean J Anesthesiol.
- 2012 May;62(5):468-473.
- doi: 10.4097/kjae.2012.62.5.468
BACKGROUND: Partially paralyzed patients may be placed in the risk of pharyngeal dysfunction. Bupivacaine acts as acetylcholine receptor ion channel blocker and may synergistically interact with rocuronium to augment NM... -
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- The Effects of Atropine and Glycopyrrolate on the Recovery from Mivacurium: Induced Neuromuscular Blockade in the Rabbit
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Kwon OK, Kim CS
- KMID: 1860463
- Korean J Anesthesiol.
- 1996 Apr;30(4):419-425.
- doi: 10.4097/kjae.1996.30.4.419
BACKGROUND: Antimuscarinic agents are used to block undesirable muscarinic effects of `anticholinesterase given to reverse the residual neuromuscular blockade produced by muscle relaxants. However, besides antimuscarinic effects, atropine was known... -
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- The antagonistic effect of neostigmine on rocuronium-, clindamycin-, or both-induced neuromuscular blocking in the rat phrenic nerve-hemidiaphragm
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Kim SS, Lee SI, Chung CJ, Lee SC
- KMID: 1766774
- Korean J Anesthesiol.
- 2011 Oct;61(4):320-326.
- doi: 10.4097/kjae.2011.61.4.320
BACKGROUND: Neostigmine augments clindamycin-induced neuromuscular block and antagonizes rocuronium-induced neuromuscular block; however, it remains unclear whether neostigmine enhances the neuromuscular blocking (NMB) that is caused by combinations of rocuronium and... -
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- Succinylcholine-induced phase II block and pharmacodynamics in rat diaphragm
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Lee SC, Lee SI, Lee JH, Lee K
- KMID: 2046786
- Anesth Pain Med.
- 2008 Oct;3(4):304-308.
BACKGROUND: Succinylcholine causes phase II block by a large dose or a prolonged exposure. There are rare data in a pharmacodynamics of phase II block. The purpose of this study... -
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- The synergistic effect of gentamicin and clindamycin on rocuronium-induced neuromuscular blockade
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Lee JH, Lee SI, Chung CJ, Lee JH, Lee SC, Choi SR, Oh JN, Bae JY
- KMID: 1798228
- Korean J Anesthesiol.
- 2013 Feb;64(2):143-151.
- doi: 10.4097/kjae.2013.64.2.143
BACKGROUND: Gentamicin reduces acetylcholine release and clindamycin causes end-plate ion channel blockade. Because of these reasons, two drugs show muscular relaxant effect and potentiate the action of nondepolarizing neuromuscular agents.... -
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- Analysis of the rocuronium-vecuronium interaction on tetanic fade based on a generalized response surface model with varying relative potencies
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Lee JH, Lee SI, Lee SC, Cho WJ
- KMID: 1782595
- Korean J Anesthesiol.
- 2009 May;56(5):559-566.
- doi: 10.4097/kjae.2009.56.5.559
BACKGROUND: Some studies have shown that rocuronium and vecuronium have additive, or synergistic effects on muscle relaxation based on the Loewe additivity. Therefore, we performed a fit of tetanic fade... -
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- The Effect of Magnesium on the Verapamil Neuromuscular Blockade in Rat Phrenic Nerve-Hemidiaphragm Preparations
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Lee SI, Lee JH, Kim DY, Kim JY
- KMID: 2299080
- Korean J Anesthesiol.
- 2004 Jun;46(6):714-718.
- doi: 10.4097/kjae.2004.46.6.714
BACKGROUND: At the neuromuscular junction, magnesium acts on the release of acetylcholine and on the excitability of sarcolemma. Verapamil inhibits acetylcholine release and enhances the autodesensitization of acetylcholine receptor ion... -
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- The Effect of Nicorandil on the Pharmacodynamics of Rocuronium
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Lee SI, Lee JH, Lee SC, Lee JM
- KMID: 2092093
- Korean J Anesthesiol.
- 2006 May;50(5):567-571.
- doi: 10.4097/kjae.2006.50.5.567
BACKGROUND: Some investigators have shown that nicorandil, a K(ATP) channel opener, depresses the neuromuscular transmission contraction of the skeletal muscle. However, others have reported that it improves the recovery of... -
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- The Effect of Pefloxacin on Rocuronium-Induced Neuromuscular Blockade in Rat Phrenic Nerve-Hemidiaphragm Preparations
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Lee SI, Lee JH, Shin HS
- KMID: 2299112
- Korean J Anesthesiol.
- 2004 Sep;47(3):403-408.
- doi: 10.4097/kjae.2004.47.3.403
BACKGROUND: At the neuromuscular junction, pefloxacin (P) may exacerbate myasthenia gravis and reduce the tau of MEPC. So here we investigated the effect of P on the neuromuscular blocking action... -
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- The Neuromuscular Effects of Glucocorticoid Administration on the Skeletal Muscle of Rats
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Shin YS, Son SC, Yoon SH, Lee WH, Kim YH, Yoon HS, Yoo YJ, Lee JU
- KMID: 2299016
- Korean J Anesthesiol.
- 2003 Mar;44(3):386-392.
- doi: 10.4097/kjae.2003.44.3.386
BACKGROUND: The administration of high doses of glucocorticoids can produce significant side effects including skeletal muscle atrophy, weakness and aberrant pharmacology. However, available reports have yielded conflicting results ranging from... -
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- Neuromuscular Blocking Actions and Mechanisms of Kanamycin, Pefloxacin and Rocuronium in the Rat Phrenic Nerve-Hemidiaphragm Preparations
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Lee JH, Lee SI
- KMID: 1860816
- Korean J Anesthesiol.
- 2003 Apr;44(4):527-543.
- doi: 10.4097/kjae.2003.44.4.527
BACKGORUND: Kanamycin (K) has been shown to block neuromuscular transmission by reducing acetylcholine release or postsynaptic action. Pefloxacin (P) may exacerbate myasthenia gravis and reduce the tau of MEPP. Rocuronium... -
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- The Effect of Kanamycin on Rocuronium Neuromuscular Blockade in Rat Hemidiaphragm-phrenic Nerve Preparations
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Lee SI, Lee JH, Lee SC, Kim SS
- KMID: 2238920
- Korean J Anesthesiol.
- 2005 Jun;48(6):635-641.
- doi: 10.4097/kjae.2005.48.6.635
BACKGROUND: Kanamycin has been shown to block neuromuscular transmission by reducing acetylcholine can release or blocking postsynaptic receptors. This study was undertaken to investigate whether kanamycin can potentiate rocuronium... -
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