Korean J Anesthesiol.
1986 Feb;19(1):66-70.
Comparative Study between Glycopyrrolate-Neostigmine and Atropine-Neostigmine in Postanesthetic Arousal
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- 1Department of Anesthesiology, School of Medicine, Won Kwang University, Iri, Korea.
Abstract
- Atropine and glycopyrrolate have been used for the reversal of non-depolarizing neuromuscular blockade as anticholinergics. Atropine may produce the central anticholinergic effect because it is a tertiary amine which can cross the blood-brain barrier. Glycopyrrolate is a quaternary ammonium compound that does not cross the blood-brain barrier. and as a result, it has no significant central anticholinergic effect. This report compares postanesthetic arousal between glycopyrrolate-neostigmine and atropine-neostigmine mixtures. We conclude that the glycopyrrolate-neostigmine mixture group have significantly more rapid arousal than the atropine-neostigmine group.
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