Korean J Anesthesiol.  1988 Aug;21(4):564-568. 10.4097/kjae.1988.21.4.564.

The Effects of Atropine and Glycopyrrolate mixed to Neostigmine on Heart Rate in Anesthetized Pediatric Patients

• Lee KS
• Park DP

• KMID: 1933127
• DOI: http://doi.org/10.4097/kjae.1988.21.4.564

Abstract

Fourty pediatric patients anesthetized with halothane-nitrous oxide-oxygen, who received pancronium for the maintenance of muscular relaxation, were divided into two groups. On anesthesia, in group l, atropine(20ug/kg) and neostigmin(40ug/kg), and in group ll, glycopyrrolate(10ug/kg) and neostigmine(40ug/kg) were injected transvenously. The changes in heart rate and arrythmis were then observed. The results were as follows: 1) The safety and effectiveness of both groups in antagonizing the muscarinic actions of neostigmine were demonstrated. 2) Glycopyrrolate produced a significantly smaller change in heart rate than atropine. 3) In both groups, arrhythmis could not be observed.

Keyword

Pediatric patients; Neostigmine; Glycopyrrolate; Atropine; Heart rate; Neuromuscular blocker

MeSH Terms

Anesthesia
Atropine*
Glycopyrrolate*
Heart Rate*
Heart*
Humans
Neostigmine*
Relaxation
Atropine
Glycopyrrolate
Neostigmine