Korean J Anesthesiol.  1987 Apr;20(2):166-171. 10.4097/kjae.1987.20.2.166.

The Effect of Atropine-Neostigmine and Glycopyrrolate-Neostigmine Mixture on Heart Rate

• Kang SK
• Choi YR
• Chung CD

• KMID: 1933314
• DOI: http://doi.org/10.4097/kjae.1987.20.2.166

Abstract

Clinically, neostigmine is most commonly used as the reversal agent for to the competitive muscle relaxants. Atropine (group 1) and glrcopyrrolate (group 2) were studied in doses of 15ug/kg, 20 ug/kg and 77ug/kg, 10ug/kg given intravenously in a mixture with neostigm-ine 40ug/kg, during operation and at the end of operation 20 ASA class I patients, aged between 15 to 60, were selected in each group. Anesthesia was maintained with enflurane (1-1.5%), N2O (2L/min), O2(2L/min) and pancuronium (50ug/kg) was used as a muscle relaxant. The results were as fellows : 1) Group 1 showed significant increase and decrease in purse rate compared with group 2. 2) Atropine neostigmine mixture significantly showed initial increase and late decrease in pulse rate than glycopyrrolate-neostigmine mixture. 3) In group 2, 20ug/kg dose of atropine, when administered in a mixture with neostigmine, showed significant initial increase in pulse rate, 15ug/kg dose of atropine showed significant late bradycardia. 4) In group 2, 7 ug/kg, 10 ug/kg dose of glycopyrrolate was not associated with initial tachy cardia but late bradycardia was obserred and 10 ug/kg dose of glycopyrrolate was associated with more stable heart rate.

MeSH Terms

Anesthesia
Atropine
Bradycardia
Cardia
Enflurane
Glycopyrrolate
Heart Rate*
Heart*
Humans
Neostigmine
Pancuronium
Atropine
Enflurane
Glycopyrrolate
Neostigmine
Pancuronium