Korean Circ J.  2006 Apr;36(4):255-260. 10.4070/kcj.2006.36.4.255.

Decrease in Plasma Adiponectin Concentrations in Patients with Vasospastic Angina

• Hong SJ
• Park CG
• Seo HS
• Rha SW
• Kim JW
• Oh DJ
• Kwon JA
• Lee KN
• Jang YS
• Ro YM

• KMID: 1859052
• DOI: http://doi.org/10.4070/kcj.2006.36.4.255

Abstract

BACKGROUND AND OBJECTIVES: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP.
SUBJECTS AND METHODS
Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants.
RESULTS
The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6+/-5.4 vs. 5.2+/-4.0 vs. 9.0+/-6.2 microgram/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP.
CONCLUSION
Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.

Keyword

Adiponectin; Coronary artery vasospasm; Acetylcholine

MeSH Terms

Acetylcholine
Acute Coronary Syndrome
Adiponectin*
Angina Pectoris
Angina, Stable
Angina, Unstable
Atherosclerosis
Chest Pain
Coronary Angiography
Coronary Artery Disease
Coronary Vasospasm
Coronary Vessels
Female
Humans
Insulin Resistance
Macrophages
Multivariate Analysis
Myocardial Infarction
Plasma*
Smoke
Smoking
Acetylcholine
Adiponectin
Smoke