Korean Circ J.  2010 Nov;40(11):573-580. 10.4070/kcj.2010.40.11.573.

Bone Mineral Density is an Independent Determinant of Left Ventricular Mass Index in the General Female Population

• Lim YH
• Shin J
• Lee JU
• Lim HK
• Hong S
• Kim MK
• Choi BY
• Kim YM

• KMID: 1826176
• DOI: http://doi.org/10.4070/kcj.2010.40.11.573

Abstract

BACKGROUND AND OBJECTIVES
Left ventricular hypertrophy (LVH) is a well known cardiovascular prognostic predictor. Osteoporosis has been suggested to be associated with cardiovascular disease. According to studies of primary hyperparathyroidism, a pathophysiological association between calcium metabolism and LVH has been suggested but is not yet fully understood. This study was performed to investigate the association between bone mineral density (BMD) and left ventricular mass index (LVMI) in a general population.
SUBJECTS AND METHODS
Data from 460 subjects among 543 subjects sampled from a general population in a rural area in Korea were analyzed. BMD, echocardiography, brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (IMT) measurement as well as the measurements of blood pressure, blood chemistry and metabolic parameters were analyzed. BMD was measured using the Sahara Clinical Bone Sonometer (Hologic Inc., Mass., USA).
RESULTS
Age of the subjects was 59.4+/-12.4 years. Males were 42.2% (n=194). In a simple correlation analysis on female subjects, age and waist circumference showed negative correlation, and body mass index (BMI) showed positive correlation with BMD. However, only age showed negative correlation with BMD in male subjects. After adjusting baPWV and carotid IMT, we found that BMD was an independent determinant of LVMI in female subjects (beta=-13.703, p=0.016), but not in male subjects (beta=-1.235, p=0.841).
CONCLUSION
BMD is a consistent and independent determining factor of LVMI, BMI and carotid IMT in postmenopausal women.

Keyword

Bone density; Hypertrophy; Heart ventricles

MeSH Terms

Africa, Northern
Blood Pressure
Body Mass Index
Bone Density
Calcium
Cardiovascular Diseases
Carotid Intima-Media Thickness
Echocardiography
Female
Heart Ventricles
Humans
Hyperparathyroidism, Primary
Hypertrophy
Hypertrophy, Left Ventricular
Korea
Male
Osteoporosis
Pulse Wave Analysis
Waist Circumference
Calcium

Figure

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  Fig. 1 Correlation between bone mineral density (BMD) and brachial ankle pulse wave velocity (baPWV), carotid intima-media thickness (IMT) and left ventricular mass index (LVMI).

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