Endocrinol Metab.  2013 Mar;28(1):33-40. 10.3803/EnM.2013.28.1.33.

The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults

• Yu JH
• Yim SH
• Yu SH
• Lee JY
• Kim JD
• Seo MH
• Jeon WS
• Park SE
• Park CY
• Lee WY
• Oh KW
• Park SW
• Rhee EJ

• KMID: 1805943
• DOI: http://doi.org/10.3803/EnM.2013.28.1.33

Abstract

BACKGROUND
We investigated the association of coronary artery calcium score (CACS) with body composition and insulin resistance in apparently healthy Korean adults.
METHODS
Nine hundred forty-five participants (mean age, 48.9 years; 628 men) in a medical check-up program were selected for analysis. Body composition was assessed by bioelectrical impedance analysis (BIA). Insulin resistance was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). The CACS was assessed by multidetector computed tomography.
RESULTS
One hundred forty-six subjects (15.4%) showed coronary artery calcification and 148 subjects (15.7%) had metabolic syndrome. CACS showed a significant positive correlation with age, fasting glucose level, waist circumference (WC), blood pressure, hemoglobin A1c, HOMA-IR, and waist-hip ratio (WHR) assessed by BIA. CACS had a negative correlation with high density lipoprotein cholesterol (HDL-C). Subjects with high CACS showed significantly higher mean WHRs and lower mean values for lean body mass compared with subjects without coronary artery calcification. In logistic regression analyses with coronary artery calcification as the dependent variable, the highest quartile of WHR showed a 3.125-fold increased odds ratio for coronary artery calcification compared with the lowest quartile after adjustment for confounding variables. When receiver operating characteristics analyses were performed with coronary artery calcification as the result variable, WHR showed the largest area under the curve (AUC) value among other variables except for age and WC in women (AUC=0.696 for WHR, 0.790 for age, and 0.719 for WC in women).
CONCLUSION
In our study population of apparently healthy Korean adults, WHR was the most significant predictor for coronary artery calcification among other confounding factors, suggesting that it may have implication as a marker for early atherosclerosis.

Keyword

Coronary artery calcium score; Waist-hip ratio; Obesity, abdominal

MeSH Terms

Adult
Atherosclerosis
Blood Pressure
Body Composition
Calcium
Cholesterol
Cholesterol, HDL
Confounding Factors (Epidemiology)
Coronary Vessels
Electric Impedance
Fasting
Female
Glucose
Hemoglobins
Homeostasis
Humans
Insulin Resistance
Lipoproteins
Logistic Models
Obesity, Abdominal
Odds Ratio
ROC Curve
Waist Circumference
Waist-Hip Ratio
Calcium
Cholesterol
Cholesterol, HDL
Glucose
Hemoglobins
Lipoproteins

Figure

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  Fig. 1 The distribution of coronary calcium score according to age group.

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  Fig. 2 Mean coronary calcium score in groups according to quartiles of waist-hip ratio in (A) men and (B) women. (A) Different letters denote significant differences between the groups in post-hoc analysis, and (B) different letters denote significant differences from 1st quartile group in post-hoc analysis.

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