Korean J Schizophr Res.  2012 Jun;15(1):34-38. 10.16946/kjsr.2012.15.1.34.

Association Study between Tryptophan Hydroxylase 2 Gene -703G/T Polymorphism and Tardive Dyskinesia

• Lee JH
• Kang SG
• Park YM
• Lee HJ
• Kim SJ
• Kim L

• KMID: 1790745
• DOI: http://doi.org/10.16946/kjsr.2012.15.1.34

Abstract

OBJECTIVES
Tardive dyskinesia (TD) is a serious and sometimes irreversible adverse effect that may develop during long-term antipsychotics treatment. Previous studies have suggested that brain serotonergic systems are related to TD vulnerability and tryptophan hydroxylase (TPH) is the rate limiting enzyme in the biosynthesis of serotonin. This study aimed to investigate the association between TPH2 gene -703G/T polymorphism (rs4570625) and antipsychotic-induced TD in the Korean schizophrenia patients.
METHODS
We investigated whether TPH2 gene -703G/T polymorphism is associated with antipsychotic-induced TD in 280 Korean schizophrenia patients. The subjects with TD (n=105) and without TD (n=175) were matched for antipsychotic drug exposure and other relevant variables.
RESULTS
There was no significant difference in the distribution of genotypic (chi2=3.00, p=0.223) and allelic (chi2=0.19, p=0.661) frequencies between patients group with TD and without TD. There was no significant difference in total Abnormal Involuntary Movement Scale score (F=1.95, p=0.362) among the genotype groups, either.
CONCLUSIONS
The present study does not support that TPH2 gene -703G/T polymorphism is involved in TD of the Korean schizophrenia subjects.

Keyword

Tardive dyskinesia; Tryptophan hydroxylase 2 gene; Schizophrenia

MeSH Terms

Antipsychotic Agents
Brain
Dyskinesias
Genotype
Humans
Movement Disorders
Schizophrenia
Serotonin
Tryptophan
Tryptophan Hydroxylase
Antipsychotic Agents
Serotonin
Tryptophan
Tryptophan Hydroxylase

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