- Acute Effect of Alcohol and Nicotine on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal and Median Raphe of Rats
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Jang MH, Shin MC, Chang HK, Lee TH, Kim KH, Kim YJ, Kim CJ
- KMID: 1607347
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):5-8.
Alcohol abuse and cigarette smoking have been on the rise worldwide and it has been reported that alcohol and nicotine influence serotonergic neuronal activity in the dorsal raphe. Serotonin (5-hydroxytryptamine,... -
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- Association Study of Tyrosine Hydroxylase and Tryptophan Hydroxylase with Schizophrenia
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Toh KY, Bang SK, Paik IH
- KMID: 2340465
- J Korean Neuropsychiatr Assoc.
- 2000 May;39(3):638-646.
Neurochemical investigation has played a major role in the search for the cause of schizophrenia. Among many hypotheses, dopamine hypothesis of schizophrenia prevails despite much criticism and qualification. Recently, evidences... -
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- An Association Study of Schizophrenics and Their Clinical Variables with Tryptophan Hydroxylase Gene Polymorphism
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Cho HS, Lee SP, Toh KY, Paik IH
- KMID: 2340371
- J Korean Neuropsychiatr Assoc.
- 1999 Sep;38(5):1130-1136.
OBJECTIVES: The genetic polymorphism of tryptophan hydroxylase (TPH) the rate-limiting enzyme in the biosynthesis of serotonin, has been to be related with various psychiatric disorders such as bipolar disorders.... -
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- Fluoxetine-induced Changes on Activity of Tryptophan Hydroxylase at RBL-2H3 Cells
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Baik SY, Jung KH, Choi MR, Yang BH, Kim SH, Choi IG, Chai YG
- KMID: 2286983
- Korean J Psychopharmacol.
- 2004 Dec;15(4):449-456.
OBJECTIVES: The aim of the present study is to explore the effect of fluoxetine on transcription, translation and activity of tryptophan hydroxylase (TPH), and intracellular level of serotonin. METHODS: The... -
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- The Tryptophan Hydroxylase A218C Polymorphism in Patients with Bipolar Disorder
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Kim WT, Kim SK
- KMID: 2286805
- Korean J Psychopharmacol.
- 2005 Sep;16(5):406-415.
OBJECTIVE: This study has been carried out to explore the genetic causes of bipolar disorder by comparing the frequency of Tryptophan Hydroxylase (TPH) A218C polymorphism between bipolar disorder patients and... -
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- Polymorphism of Tryptophan Hydroxylase Gene in Alcohol Dependent Patients
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Hong JB, Lee SI, Shin CJ, Kim H, Chi KW, Chung IW
- KMID: 2364341
- J Korean Neuropsychiatr Assoc.
- 2001 Jul;40(4):718-726.
OBJECTIVES: This study was performed to explore the association of tryptophan hydroxylase(TPH) gene with diagnosis of alcohol dependence and/or clinical characteristics such as age of onset, family history, and severity... -
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- Association Study between Tryptophan Hydroxylase 2 Gene -703G/T Polymorphism and Tardive Dyskinesia
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Lee JH, Kang SG, Park YM, Lee HJ, Kim SJ, Kim L
- KMID: 1790745
- Korean J Schizophr Res.
- 2012 Jun;15(1):34-38.
- doi: 10.16946/kjsr.2012.15.1.34
OBJECTIVES: Tardive dyskinesia (TD) is a serious and sometimes irreversible adverse effect that may develop during long-term antipsychotics treatment. Previous studies have suggested that brain serotonergic systems are related to... -
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- New Avenues in the LRP5-mediated Bone Mass Acquisition
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Choi JY
- KMID: 1464230
- Korean J Bone Metab.
- 2012 May;19(1):1-9.
- doi: 10.11005/kjbm.2012.19.1.1
Lipoprotein receptor-related protein (LRP5) signaling is well correlated with the bone mass in both human and mice. Loss-of-function mutations of LRP5 result in osteopenia or osteoporosis. In contrast, gain-of-function mutations... -
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- An Association Study of the A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene with Eating Disorders in a Korean Population: A Pilot Study
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Kim YR, Woo JM, Heo SY, Kim JH, Lim SJ, Yu BH
- KMID: 2315815
- Psychiatry Investig.
- 2009 Mar;6(1):44-49.
OBJECTIVE: We examined the association between the tryptophan hydroxylase 1 (TPH1) gene and eating disorders focusing on obsessionality. METHODS: The sample included 62 women with a lifetime diagnosis of anorexia... -
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- No Association between Genetic Polymorphism of Tryptophan Hydroxylase A218C and Serotonin Transporter Linked Polymorphic Region and Panic Disorder
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Choi YH, Woo JM, Park HK, Yoon KS, Cho DY, Lee MS
- KMID: 2248982
- Korean J Biol Psychiatry.
- 2004 Nov;11(2):136-145.
OBJECTIVES: Genetic variations of the tryptophan hydroxylase(TPH) gene and the serotonin transporter linked polymorphic region(5-HTTLPR) polymorphism have been associated with its functional capacity. The authors investigated whether the allelic constitution... -
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- Association Between Suicide Attempts in Patients With Depressive Disorder and Tryptophan Hydroxylase A218C Polymorphism
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Shim SH, Hwang BY, Kwon YJ, Jung HY, Lee BH, Kim YK
- KMID: 2341419
- J Korean Neuropsychiatr Assoc.
- 2008 Mar;47(2):142-152.
OBJECTIVES: Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital... -
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- Relationship between Sleep, Suicide, and Serotonin
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Park YM
- KMID: 2317543
- Sleep Med Psychophysiol.
- 2013 Jun;20(1):5-9.
One of hypothesis is that sleep loss related to a decrease in serotonergic activity plays a significant role in attempted suicide. A growing evidence suggests that central serotonergic activity plays... -
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- Suicide : Gene-Environment Interaction
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Kim YK
- KMID: 2249836
- Korean J Biol Psychiatry.
- 2010 May;17(2):65-69.
Gene-environment interactions are important in pathogenesis of suicide or suicidal behavior. Twin and adoption studies and family studies show that genetic factors play a critical role in suicide or suicidal... -
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- Two dinucleotide repeat polymorphisms (AC/TG and GT/CA) in the 5' upstream region of the mouse tryptophan hydroxylase gene
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Yim SV, Chi SG, Chung SH, Lee HJ, Kim MJ, Park SJ, Jung JC, Chung JH
- KMID: 2071551
- Korean J Physiol Pharmacol.
- 1999 Oct;3(5):501-505.
Tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis, is primarily expressed in serotonergic neurons of the raphe nuclei. Simple tandem repeat polymorphisms, typically one to four nucleotides long, are tandemly repeated several... -
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- No Evidence of an Association between A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene and Aggression in Schizophrenia in a Korean Population
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Kim YR, Lee JY, Min SK
- KMID: 1779602
- Yonsei Med J.
- 2010 Jan;51(1):27-32.
- doi: 10.3349/ymj.2010.51.1.27
PURPOSE: We investigated the association between the tryptohan hydroxylase 1 (TPH1) gene and aggression in schizophrenia in a Korean population. MATERIALS AND METHODS: The sample included 61 aggressive patients as... -
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- Biological and Genetic Prediction Factors Associated with Suicidal Behavior
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Kim YK
- KMID: 2249005
- Korean J Biol Psychiatry.
- 2005 May;12(1):3-12.
Most suicides(about 90%) occur in the context of psychiatric disorders. Prediction of suicide risk in patients with mental illness is very important in preventing suicide attempts. However, current approaches to... -
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- The Genetic Factors Affecting Drinking Behaviors of Korean Young Adults with Variant Aldehyde Dehydrogenase 2 Genotype
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Kim SK, Lee SI, Shin CJ, Son JW, Ju G
- KMID: 2315914
- Psychiatry Investig.
- 2010 Dec;7(4):270-277.
OBJECTIVE: We determined whether aldehyde dehydrogenase 2 (ALDH2) activity alters the way in which drinking behaviors are affected by gene polymorphisms of other alcohol-metabolizing enzymes and serotonin-related proteins. METHODS: Through a... -
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- The effect of both oophorectomy on serotonin level in cerebral cortex and hippocampus of the female Sprague-Dawley rat
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Ko EM, Jeon HA, Park MC
- KMID: 2262110
- Korean J Obstet Gynecol.
- 2000 Nov;43(11):1926-1931.
OBJECTIVE: The purpose of this study is to investigate the effect of chronic deprivation of estradiol on the serotonin level in Sprague-Dawley rat's cerebral cortex and hippocampus. METHODS: One hundred... -
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- Effects on 5-HT and Ach in the Rat by the I.C.V Injection of PCPA
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Pae YS
- KMID: 1965083
- Ewha Med J.
- 1993 Dec;16(4):321-330.
- doi: 10.12771/emj.1993.16.4.321
PCPA is a drug which depletes serotonin by inhibiting tryptophan hydroxylase activity. Recent evidence indicates that the ascending cholinergic projection from the basal forebrain and ascending serotonergic projections from the brain... -
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- Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population
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Choi KY, Yoon HK, Kim YK
- KMID: 2315867
- Psychiatry Investig.
- 2010 Mar;7(1):60-67.
OBJECTIVE: The aim of the present study was to examine the association between serotonin-related gene polymorphisms and bipolar disorder in the Korean population. In addition, we sought to explore the... -
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