- Treadmill Exercise Ameliorates Chemotherapy-Induced Muscle Weakness and Central Fatigue by Enhancing Mitochondrial Function and Inhibiting Apoptosis
-
Park SS, Park HS, Jeong H, Kwak HB, No MH, Heo JW, Yoo SZ, Kim TW
- KMID: 2448805
- Int Neurourol J.
- 2019 Feb;23(Suppl 1):S32-S39.
- doi: 10.5213/inj.1938046.023
PURPOSE: Chemotherapy is associated with the side effects including damage to the mitochondrial DNA. Doxorubicin (DOX) serves as a chemotherapeutic agent for the patients with breast cancer or prostate cancer.... -
- CITED
-
- Close
- SHARE
-
- Close
- Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice
-
Moon EJ, Ko IG, Kim SE, Jin JJ, Hwang L, Kim CJ, An H, Lee BJ, Yi JW
- KMID: 2426692
- Int Neurourol J.
- 2018 Oct;22(Suppl 3):S139-S146.
- doi: 10.5213/inj.1836228.114
PURPOSE: Sleep deprivation induces depressive symptoms. Dexmedetomidine is a α2-adrenoreceptor agonist and this drug possesses sedative, anxiolytic, analgesic, and anesthetic-sparing effect. In this study, the action of dexmedetomidine on sleep... -
- CITED
-
- Close
- SHARE
-
- Close
- Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome
-
Dussik CM, Hockley M, Grozić A, Kaneko I, Zhang L, Sabir MS, Park J, Wang J, Nickerson , Yale SH, Rall CJ, Foxx-Orenstein AE, Borror CM, Sandrin TR, Jurutka PW
- KMID: 2417277
- J Neurogastroenterol Motil.
- 2018 Jan;24(1):96-106.
- doi: 10.5056/jnm17021
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a multifaceted disorder that afflicts millions of individuals worldwide. IBS is currently diagnosed based on the presence/duration of symptoms and systematic exclusion of other... -
- CITED
-
- Close
- SHARE
-
- Close
- Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity
-
Oh CM, Park S, Kim H
- KMID: 2162080
- Diabetes Metab J.
- 2016 Apr;40(2):89-98.
- doi: 10.4093/dmj.2016.40.2.89
Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter.... -
- CITED
-
- Close
- SHARE
-
- Close
- Stress-Induced Depression Is Alleviated by Aerobic Exercise Through Up-Regulation of 5-Hydroxytryptamine 1A Receptors in Rats
-
Kim TW, Lim BV, Baek D, Ryu DS, Seo JH
- KMID: 2380823
- Int Neurourol J.
- 2015 Mar;19(1):27-33.
- doi: 10.5213/inj.2015.19.1.27
PURPOSE: Stress is associated with depression, which induces many psychiatric disorders. Serotonin, also known as 5-hydroxy-tryptamine (5-HT), acts as a biochemical messenger and regulator in the brain. It also mediates... -
- CITED
-
- Close
- SHARE
-
- Close
- Relationship between Sleep, Suicide, and Serotonin
-
Park YM
- KMID: 2317543
- Sleep Med Psychophysiol.
- 2013 Jun;20(1):5-9.
One of hypothesis is that sleep loss related to a decrease in serotonergic activity plays a significant role in attempted suicide. A growing evidence suggests that central serotonergic activity plays... -
- CITED
-
- Close
- SHARE
-
- Close
- Association Study between Tryptophan Hydroxylase 2 Gene -703G/T Polymorphism and Tardive Dyskinesia
-
Lee JH, Kang SG, Park YM, Lee HJ, Kim SJ, Kim L
- KMID: 1790745
- Korean J Schizophr Res.
- 2012 Jun;15(1):34-38.
- doi: 10.16946/kjsr.2012.15.1.34
OBJECTIVES: Tardive dyskinesia (TD) is a serious and sometimes irreversible adverse effect that may develop during long-term antipsychotics treatment. Previous studies have suggested that brain serotonergic systems are related to... -
- CITED
-
- Close
- SHARE
-
- Close
- New Avenues in the LRP5-mediated Bone Mass Acquisition
-
Choi JY
- KMID: 1464230
- Korean J Bone Metab.
- 2012 May;19(1):1-9.
- doi: 10.11005/kjbm.2012.19.1.1
Lipoprotein receptor-related protein (LRP5) signaling is well correlated with the bone mass in both human and mice. Loss-of-function mutations of LRP5 result in osteopenia or osteoporosis. In contrast, gain-of-function mutations... -
- CITED
-
- Close
- SHARE
-
- Close
- The Genetic Factors Affecting Drinking Behaviors of Korean Young Adults with Variant Aldehyde Dehydrogenase 2 Genotype
-
Kim SK, Lee SI, Shin CJ, Son JW, Ju G
- KMID: 2315914
- Psychiatry Investig.
- 2010 Dec;7(4):270-277.
OBJECTIVE: We determined whether aldehyde dehydrogenase 2 (ALDH2) activity alters the way in which drinking behaviors are affected by gene polymorphisms of other alcohol-metabolizing enzymes and serotonin-related proteins. METHODS: Through a... -
- CITED
-
- Close
- SHARE
-
- Close
- Suicide : Gene-Environment Interaction
-
Kim YK
- KMID: 2249836
- Korean J Biol Psychiatry.
- 2010 May;17(2):65-69.
Gene-environment interactions are important in pathogenesis of suicide or suicidal behavior. Twin and adoption studies and family studies show that genetic factors play a critical role in suicide or suicidal... -
- CITED
-
- Close
- SHARE
-
- Close
- Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population
-
Choi KY, Yoon HK, Kim YK
- KMID: 2315867
- Psychiatry Investig.
- 2010 Mar;7(1):60-67.
OBJECTIVE: The aim of the present study was to examine the association between serotonin-related gene polymorphisms and bipolar disorder in the Korean population. In addition, we sought to explore the... -
- CITED
-
- Close
- SHARE
-
- Close
- No Evidence of an Association between A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene and Aggression in Schizophrenia in a Korean Population
-
Kim YR, Lee JY, Min SK
- KMID: 1779602
- Yonsei Med J.
- 2010 Jan;51(1):27-32.
- doi: 10.3349/ymj.2010.51.1.27
PURPOSE: We investigated the association between the tryptohan hydroxylase 1 (TPH1) gene and aggression in schizophrenia in a Korean population. MATERIALS AND METHODS: The sample included 61 aggressive patients as... -
- CITED
-
- Close
- SHARE
-
- Close
- Vardenafil Increases Cell Proliferation in the Dentate Gyrus through Enhancement of Serotonin Expression in the Rat Dorsal Raphe
-
Kim TS, Ko IG, Sung YH, Kim SE, Kim BK, Park SK, Shin MS, Kim CJ, Yoon SJ, Kim KH
- KMID: 1783139
- J Korean Med Sci.
- 2009 Dec;24(6):1099-1104.
- doi: 10.3346/jkms.2009.24.6.1099
This study was conducted to evaluate the effects of vardenafil (Levitra), a phosphodiesterase-5 (PDE-5) inhibitor, on cell proliferation in the hippocampal dentate gyrus and on 5-hyroxytryptamine (5-HT, serotonin) synthesis and... -
- CITED
-
- Close
- SHARE
-
- Close
- An Association Study of the A218C Polymorphism of the Tryptophan Hydroxylase 1 Gene with Eating Disorders in a Korean Population: A Pilot Study
-
Kim YR, Woo JM, Heo SY, Kim JH, Lim SJ, Yu BH
- KMID: 2315815
- Psychiatry Investig.
- 2009 Mar;6(1):44-49.
OBJECTIVE: We examined the association between the tryptophan hydroxylase 1 (TPH1) gene and eating disorders focusing on obsessionality. METHODS: The sample included 62 women with a lifetime diagnosis of anorexia... -
- CITED
-
- Close
- SHARE
-
- Close
- Association Between Suicide Attempts in Patients With Depressive Disorder and Tryptophan Hydroxylase A218C Polymorphism
-
Shim SH, Hwang BY, Kwon YJ, Jung HY, Lee BH, Kim YK
- KMID: 2341419
- J Korean Neuropsychiatr Assoc.
- 2008 Mar;47(2):142-152.
OBJECTIVES: Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Genetic and Environmental Factors on the Depression in Early Adulthood
-
Kim SK, Lee SI, Shin CJ, Son JW, Eom SY, Kim H
- KMID: 1770031
- Korean J Biol Psychiatry.
- 2008 Feb;15(1):14-22.
OBJECTIVES: The authors purposed to present data for explaining gene-environmental interaction causing depressive disorder by examining the effects of genetic factors related to the serotonin system and environmental factors such... -
- CITED
-
- Close
- SHARE
-
- Close
- The Tryptophan Hydroxylase A218C Polymorphism in Patients with Bipolar Disorder
-
Kim WT, Kim SK
- KMID: 2286805
- Korean J Psychopharmacol.
- 2005 Sep;16(5):406-415.
OBJECTIVE: This study has been carried out to explore the genetic causes of bipolar disorder by comparing the frequency of Tryptophan Hydroxylase (TPH) A218C polymorphism between bipolar disorder patients and... -
- CITED
-
- Close
- SHARE
-
- Close
- Biological and Genetic Prediction Factors Associated with Suicidal Behavior
-
Kim YK
- KMID: 2249005
- Korean J Biol Psychiatry.
- 2005 May;12(1):3-12.
Most suicides(about 90%) occur in the context of psychiatric disorders. Prediction of suicide risk in patients with mental illness is very important in preventing suicide attempts. However, current approaches to... -
- CITED
-
- Close
- SHARE
-
- Close
- Fluoxetine-induced Changes on Activity of Tryptophan Hydroxylase at RBL-2H3 Cells
-
Baik SY, Jung KH, Choi MR, Yang BH, Kim SH, Choi IG, Chai YG
- KMID: 2286983
- Korean J Psychopharmacol.
- 2004 Dec;15(4):449-456.
OBJECTIVES: The aim of the present study is to explore the effect of fluoxetine on transcription, translation and activity of tryptophan hydroxylase (TPH), and intracellular level of serotonin. METHODS: The... -
- CITED
-
- Close
- SHARE
-
- Close
- No Association between Genetic Polymorphism of Tryptophan Hydroxylase A218C and Serotonin Transporter Linked Polymorphic Region and Panic Disorder
-
Choi YH, Woo JM, Park HK, Yoon KS, Cho DY, Lee MS
- KMID: 2248982
- Korean J Biol Psychiatry.
- 2004 Nov;11(2):136-145.
OBJECTIVES: Genetic variations of the tryptophan hydroxylase(TPH) gene and the serotonin transporter linked polymorphic region(5-HTTLPR) polymorphism have been associated with its functional capacity. The authors investigated whether the allelic constitution... -
- CITED
-
- Close
- SHARE
-
- Close
