Korean J Intern Med.  2005 Sep;20(3):237-242. 10.3904/kjim.2005.20.3.237.

Double Autologous Stem Cell Transplantation for Multiple Myeloma: A Korean Single Center Study

• Ko OB
• Kim S
• Shim H
• Lee JH
• Ahn JM
• Yoon SM
• Jeon MH
• Do IN
• Lee SY
• Kim YG
• Kim SW
• Kim SB
• Kim SH
• Lee JS
• Kim W
• Park CJ
• Chi HS
• Suh C

• KMID: 1782236
• DOI: http://doi.org/10.3904/kjim.2005.20.3.237

Abstract

BACKGROUND
Although high dose chemotherapy coupled with an autologous stem cell transplantation (ASCT) is widely accepted as effective therapy for multiple myeloma (MM), few reports are available in Korea, especially in the area of double ASCT. We present the results of an institutional retrospective study of 12 patients with MM treated by double ASCT. METHODS: Eligible patients received induction therapy using vincristine, adriamycin, dexamethasone (VAD), and mobilization was performed using cyclophosphamide plus lenograstim. High-dose melphalan (total 200 mg/m2) was used to condition the ASCT. RESULTS: The median interval from diagnosis to ASCT was 6 months (range, 1.8-15.3 months). The median interval between the 1st and 2nd ASCT was 4.4 months (range 2.1-48.7 months). The median follow up was 18.3 months (range 8.1-50.5 months) for the nine surviving patients. No therapy-related mortality occurred. Following induction chemotherapy, two patients experienced CR. Following double ASCT, eight patients experienced CR. The 5 year OS was 59%. The median duration of event free survival was 2.13 years (95% CI, 0.84-3.42). CONCLUSION: Although the results of study did not demonstrate the advantage of double ASCT, this is the first report to outline the outcome of double ASCT for Korean MM patients.

Keyword

Multiple myeloma; Autologous; Stem cell transplantation

MeSH Terms

Vincristine/administration & dosage
Transplantation, Autologous
*Stem Cell Transplantation
Retrospective Studies
Recombinant Proteins/administration & dosage
Multiple Myeloma/drug therapy/*therapy
Middle Aged
Male
Korea
Humans
Granulocyte Colony-Stimulating Factor/administration & dosage
Female
Doxorubicin/administration & dosage
Dexamethasone/administration & dosage
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Antineoplastic Agents/*therapeutic use
Aged
Adult