Blood Res.  2018 Sep;53(3):254-256. 10.5045/br.2018.53.3.254.

Emergence of chronic myeloid leukemia following autologous stem cell transplantation in a young woman with multiple myeloma

• Barrett A
• Glavey S
• Sargent J
• Thornton P
• Murphy P
• Quinn J

• KMID: 2429328
• DOI: http://doi.org/10.5045/br.2018.53.3.254

Abstract

No abstract available.

MeSH Terms

Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Multiple Myeloma*
Stem Cell Transplantation*
Stem Cells*

Figure

• 

  Fig. 1 Bone marrow at the time of multiple myeloma (MM) diagnosis. A hypercellular particle with atypical plasma cells under low power (A). Numerous atypical plasma cells under high power (B).

• 

  Fig. 2 Bone marrow at the time of chronic myeloid leukemia (CML) diagnosis. A hypercellular particle under low power (A). A high-power view of granulocytic hyperplasia (B).

Reference

1. Lee JY, Lee SM, Yoon HK, Kim KH, Choi MY, Lee WS. A case of synchronous multiple myeloma and chronic myeloid leukemia. Blood Res. 2017; 52:219–222.

2. Thomas A, Mailankody S, Korde N, Kristinsson SY, Turesson I, Landgren O. Second malignancies after multiple myeloma: from 1960s to 2010s. Blood. 2012; 119:2731–2737.

3. Wolleschak D, Heidel FH. Chronic myelogenous leukemia evolving after treatment of multiple myeloma. Blood. 2016; 128:146.

4. Alsidawi S, Ghose A, Qualtieri J, Radhakrishnan N. A case of multiple myeloma with metachronous chronic myeloid leukemia treated successfully with bortezomib, dexamethasone, and dasatinib. Case Rep Oncol Med. 2014; 2014:962526.

5. Pessach I, Bartzis V, Tzenou T, et al. Multiple myeloma and chronic myelogenous leukemia; an uncommon coexistence in 2 patients, with literature review. Ann Hematol Oncol. 2015; 2:1030.

6. Nakagawa M, Noto S, Kobayashi H, Hayashi M. A case of a 47 year old man who developed chronic myelogenous leukemia after therapy for multiple myeloma. J Obihiro Kosei Gen Hosp. 2003; 6:101–106.

7. Nitta M, Tsuboi K, Yamashita S, et al. Multiple myeloma preceding the development of chronic myelogenous leukemia. Int J Hematol. 1999; 69:170–173.

8. Klenn PJ, Hyun BH, Lee YH, Zheng WY. Multiple myeloma and chronic myelogenous leukemia-a case report with literature review. Yonsei Med J. 1993; 34:293–300.

9. MacSween JM, Langley GR. Light-chain disease (hypogammaglobulinemia and Bence Jones proteinuria) and sideroblastic anemia-preleukemic chronic granulocytic leukemia. Can Med Assoc J. 1972; 106:995–998.

10. Ragupathi L, Najfeld V, Chari A, Petersen B, Jagannath S, Mascarenhas J. A case report of chronic myelogenous leukemia in a patient with multiple myeloma and a review of the literature. Clin Lymphoma Myeloma Leuk. 2013; 13:175–179.