Yonsei Med J.  1993 Sep;34(3):293-300. 10.3349/ymj.1993.34.3.293.

Multiple myeloma and chronic myelogenous leukemia: a case report with literature review

  • 1Department of Pathology and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, PA 19107.


This is the case of a 71 year old male who developed multiple myeloma (MM) and chronic myelogenous leukemia (CML) within a two year period. The patient initially presented with osteolytic lesions of the lumbar spine, and following the initial work-up a diagnosis of multiple myeloma with an IgG kappa paraproteinemia was made and appropriate treatment was given. Two years later the patient developed a progressively worsening leukocytosis which was found to be due to Philadelphia Chromosome (Ph1) positive CML. The occurrence in the same patient of two distinct hematologic malignancies suggests a neoplastic transformation of a pluripotent stem cell. A review of the literature appears to support the existence of a relationship between MM and CML as well as a relationship between MM and the myeloproliferative disorders.


Multiple myeloma; chronic myelogenous leukemia

MeSH Terms

Case Report
Cell Transformation, Neoplastic/pathology
Hematopoietic Stem Cells/pathology
Leukemia, Myeloid, Chronic/*pathology
Multiple Myeloma/*pathology

Cited by  1 articles

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