J Korean Med Sci.  2005 Feb;20(1):146-149. 10.3346/jkms.2005.20.1.146.

Collagenous Gastritis in A Korean Child: A Case Report

• Park S
• Kim DH
• Choe YH
• Suh YL

• KMID: 1781743
• DOI: http://doi.org/10.3346/jkms.2005.20.1.146

Abstract

Collagenous gastritis, a counterpart of collagenous colitis, is an extremely rare disorder. The first case of collagenous gastritis in a Korean boy in his preteens who had been receiving treatment for refractory iron deficiency anemia has been reported. The patient had been suffering from intermittent abdominal pain, recurrent bloodtinged vomiting and poor oral intake. The gastric endoscopy revealed diffuse cobblestone appearance of the mucosa with easy touch bleeding throughout the stomach but no abnormalities in the esophagus, duodenum, and colon. Pathologic examination of the gastric biopsies from the antrum, body and cardia showed a subepithelial collagen deposition with entrapped dilated capillaries, moderate infiltrates of lymphoplasma cells and eosinophils of the lamina propria, and marked hypertrophy of the muscularis mucosa. The collagen deposition appeared as discontinuous bands with focally irregular extension into the deeper part of the antral mucosa. It measured up to 150 micrometer. Helicobacter pylori infection was not detected. The biopsies from the duodenum, esophagus and colon revealed no pathologic abnormalities.

Keyword

Gastritis; Gastritis, Collagenous; Child; Endoscopy

MeSH Terms

Biopsy
Child
Colitis/*diagnosis/pathology
Collagen/metabolism
Endoscopy
Gastric Mucosa/pathology
Gastritis/pathology
Gastrointestinal Hemorrhage/diagnosis/pathology
Helicobacter pylori/metabolism
Humans
Korea
Male
Mucous Membrane/pathology
Stomach Diseases/diagnosis/pathology

Figure

• 

  Fig. 1 Endoscopy of the stomach shows polypoid mucosal nodules around the pyloric ring.

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  Fig. 2 Endoscopic biopsy from the antral mucosa shows subepithelial collagenous deposition, slough of surface epithelium, inflammatory cell infiltration, and hypertrophy of muscularis mucosa (H&E, ×100).

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  Fig. 3 High power magnification of Fig. 2. The subepithelial collagenous bands contains entrapped dilated capillaries and inflammatory cells (H&E, ×200).

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