Yonsei Med J.  2011 Mar;52(2):220-226. 10.3349/ymj.2011.52.2.220.

Comparison of Predictability of Cardiovascular Events between Each Metabolic Component in Patients with Metabolic Syndrome Based on the Revised National Cholesterol Education Program Criteria

• Hwang IC
• Kim KK
• Jee SH
• Kang HC

• KMID: 1779655
• DOI: http://doi.org/10.3349/ymj.2011.52.2.220

Abstract

PURPOSE
The prevalence of metabolic syndrome (MetS) generally varies depending on its diagnostic definition, and many different definitions inevitably lead to substantial confusion and lack of comparability between studies. Despite extensive research, there is still no gold standard for the definition of MetS, which continues to be a matter of debate. In this study, we investigate whether and to what extent its individual components are related to the risk of cardiovascular disease (CVD) in Korean population.
MATERIALS AND METHODS
We used data from the 2005 Korea National Health and Nutrition Examination Survey, which is a nationally representative survey of the noninstitutionalized civilian population. The study sample consisted of 1,406 Korean adults (587 men, 819 women) who were diagnosed with MetS based on the revised National Cholesterol Education Program (NCEP) criteria. Central obesity is defined as a waist circumference cutoff point reported in Asia-Pacific criteria for obesity based on waist circumference by the World Health Organization. CVD was defined as presence of stroke, myocardial infarction, or angina pectoris on a medical history questionnaire.
RESULTS
The CVD prevalence among the subjects was 6.8% for men and 8.6% for women. Besides age, the components of MetS showing a significant difference in the number of CVD events were high fasting glucose (FG) in men and high blood pressure (BP) and high FG in women. After adjusting for gender and age, high FG was shown to yield a significant difference (odds ratio: unadjusted 2.08, adjusted 1.81), alone among all MetS components. However, after adjusting for only age, no significant difference was found.
CONCLUSION
Fasting glucose level is the highest predicting factor for CVD in Korean patients with MetS based on the revised NECP definition.

Keyword

Metabolic components; cardiovascular disease; fasting glucose

MeSH Terms

Age Factors
Blood Glucose/analysis
Cardiovascular Diseases/epidemiology/*etiology
Chi-Square Distribution
Female
Health Promotion
Health Surveys
Humans
Hypertension/complications/epidemiology
Male
Metabolic Syndrome X/complications/*diagnosis/epidemiology
Middle Aged
Odds Ratio
Republic of Korea/epidemiology
Risk Factors
Sex Factors

Figure

• 

  Fig. 1 Odds ratio of each metabolic component for occurrence of cardiovascular events in all subjects. WC, waist circumference; TG, triglycerides; HDL, high density lipoprotein; BP, blood pressure; FG, fasting glucose.

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