Korean Circ J.  2005 Jul;35(7):507-512. 10.4070/kcj.2005.35.7.507.

Comparison of the Cobalt Alloy and Stainless Steel Core(r) Stent in a Porcine Coronary Restenosis Model

• Kim JY
• Yoon J
• Jung IH
• Wang HS
• Ahn MS
• Lee KH
• Yoo BS
• Lee SH
• Choe KH
• Jang Y
• Ahn JM
• Ryu YS

• KMID: 1769289
• DOI: http://doi.org/10.4070/kcj.2005.35.7.507

Abstract

BACKGROUND AND OBJECTIVES
The stent material and thickness may influence the rate of restenosis following coronary artery stenting. A thin strut cobalt-alloy stent has been developed in an attempt to reduce the restenosis rate, while maintaining the radiopacity and radial strength. The purpose of this study was to compare a stainless steel Core(r) stent (thickness: 90 micrometer/HUMED Co. Ltd, Korea) with that of a cobalt alloy Core(r) stent (thickness: 60 micrometer/HUMED Co. Ltd, Korea) in a porcine coronary stent restenosis model.
MATERIALS AND METHODS
The cobalt alloy (Co-alloy) and stainless steel (SS) stents were implanted in 24 porcine coronary arteries. Four weeks after stenting, the pigs were sacrificed after quantitative coronary angiography (QCA). The coronary arteries were perfusion-fixed and stained, and a pathological examination performed by computer-aided histomorphometry.
RESULTS
The minimal luminal diameter at 4 weeks was larger in the Co-alloy than the SS group according to the QCA (1.8+/-0.8 mm vs. 2.7+/-0.8 mm, p=0.019). The neointimal area was significantly smaller in the Co-alloy than the SS group (1.96+/-0.68 mm2 vs. 0.89+/-0.27 mm2, p<0.001). The intima/media area ratio was significant lower in the Co-alloy than the SS group (1.33+/-0.46 vs. 0.69+/-0.21, p=0.003).
CONCLUSION
The thin strut cobalt alloy Core(r) stent significantly reduces the neointimal formation compared to the stainless steel Core(r) stent in a porcine coronary stent injury model.

Keyword

Coblat alloys; Coronary restenosis; Stents; Animal model

MeSH Terms

Alloys*
Cobalt*
Coronary Angiography
Coronary Restenosis*
Coronary Vessels
Models, Animal
Phenobarbital
Stainless Steel*
Stents*
Swine
Alloys
Cobalt
Phenobarbital
Stainless Steel