Korean Circ J.  2001 Jul;31(7):655-661. 10.4070/kcj.2001.31.7.655.

Comparison of Core(R) stent and Palmaz-Schatz(R) stent in a Porcine Stent Restenosis Model

• Choi D
• Choi SH
• Cho DK
• Kyung HD
• Cho JR
• Kim JS
• Oh SJ
• Kwon SH
• Jang Y
• Cho SY

• KMID: 2029551
• DOI: http://doi.org/10.4070/kcj.2001.31.7.655

Abstract

BACKGROUND AND OBJECTIVES
The purpose of this study is to compare new Core(R) stent and Palmaz-Schatz(R) (PS)stent in a porcine coronary stent restenosis model.
METHODS
Twelve pigs underwent balloon injury and followed by implantation of oversized, tubular types of Core(R) and PS(R) stents (stent/artery ratio 1.2:1) in twenty-four coronary arteries. Quantitative analyses of initial and follow-up coronary angiograms at 4 weeks after stenting were performed. By morphometric analysis, the extents of injury and neointimal area were compared between two stented groups. The stent flexibility and longitudinal staightening effect were compared between two groups by the bending test and measurement of the angle changes.
RESULTS
1) Reference vessel diameter, stented artery diameter, and diameter stenosis were not different between two groups. 2) The neointimal area was significantly smaller in the Core(R) stent group than in the PS(R) stent group (1.81+/-0.67 mm2 vs 2.93+/-0.94 mm2, p=0.006). 3) Core(R) stent had more flexible property than PS(R) stent. 4) The angle changes after stent implantation were not different between two groups(13.2+/-9.0, 14.4+/-11.1, p=0.88).
CONCLUSION
Core(R) stent is effective in the inhibition of neointimal formation in a porcine coronary stent restenosis model. And this results may be due to more improved flexibility of the Core(R) stent and further clinical trials may be needed.

Keyword

Porcine model; Stents; Restenosis

MeSH Terms

Arteries
Constriction, Pathologic
Coronary Vessels
Follow-Up Studies
Pliability
Stents*
Swine