J Korean Acad Periodontol.  1999 Jun;29(2):325-332. 10.5051/jkape.1999.29.2.325.

In Vitro Antibacterial Effect of a Mouthrinse Containing CPC (Cetylpyridinium Chloride), NaF and UDCA(ursodeoxycholic acid) against Major Periodontopathogens

• Kim CK
• Choi BK
• Yoo YJ
• Kim SN
• Seok JK
• Kim MM

• KMID: 1739580
• DOI: http://doi.org/10.5051/jkape.1999.29.2.325

Abstract

The antibacterial efficacy of a mouthrinse(Denta Gargle) containing CPC(cetylpyridinium chloride), NaF and UDCA(ursodeoxycholic acid), on major periodontopathogens, was in vitro examined and compared with that of Listerine by a broth dilution method. The bacteria tested were Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Fusobacterium nucleatum subsp. vincentii, Prevotella intermedia, Porphyromonas gingivalis and Treponema denticola. The growth of all the bacteria were completely inhibited by a 1-min exposure to the both mouthrinses. When diluted at 1:5 or more, all bacteria analyzed but P. intermedia were not inhibited by Listerine. In contrast, Denta Gargle showed highly increased maximum inhibitory dilutions(MID) against all periodontopathogens included in this study, with MIDs ranging from 5-fold(F. nucleatum) to 160-fold dilutions(P. intermedia). The MIDs against A. actinomycetemcomitans, B. forsythus, P. gingivalis and T. denticola. were 1:40, 1:80, 1:80 and 1:80, respectively.

Keyword

Mouthrinse; Cetylpyridinium chloride; Periodontopathogens; Maximum inhibitory dilutions(MID)

MeSH Terms

Aggregatibacter actinomycetemcomitans
Bacteria
Bacteroides
Cetylpyridinium
Fusobacterium nucleatum
Porphyromonas gingivalis
Prevotella intermedia
Treponema denticola
Cetylpyridinium