J Periodontal Implant Sci.  2017 Jun;47(3):134-142. 10.5051/jpis.2017.47.3.134.

The antiplaque and bleeding control effects of a cetylpyridinium chloride and tranexamic acid mouth rinse in patients with gingivitis

• Lee JE
• Lee JM
• Lee Y
• Park JW
• Suh JY
• Um HS
• Kim YG

• KMID: 2383827
• DOI: http://doi.org/10.5051/jpis.2017.47.3.134

Abstract

PURPOSE
This study aimed to evaluate the effects of a cetylpyridinium chloride (CPC) and tranexamic acid (TXA) mouth rinse on patients with gingivitis.
METHODS
This randomized, placebo-controlled, double-blind, parallel-group, clinical trial included 45 healthy adults with gingivitis, who were randomized into 2 groups. The experimental group used a 0.05% CPC and 0.05% TXA mouth rinse, and the control group used a placebo mouth rinse. The following clinical indices were assessed at baseline, at 3 weeks, and at 6 weeks: the Turesky-Quigley-Hein plaque index (QHI), the Löe-Silness gingival index (GI), and bleeding on marginal probing (BOMP). The subjects used the mouth rinse during the experimental period for 20 seconds, 4-5 times daily (10 mL each time).
RESULTS
There were no significant differences in the clinical indices between the groups at baseline. In the experimental group (CPC+TXA), a statistically significant improvement was evident in the QHI, GI, and BOMP at 3 and 6 weeks. These results were similar to those observed in the control group at 3 and 6 weeks, although the change in BOMP was not statistically significant in that group. At 6 weeks, the experimental group had a significantly lower mean score for the QHI than the control group.
CONCLUSIONS
This study demonstrated that a CPC and TXA mouth rinse exhibited significant antiplaque and anti-gingivitis efficacy, and had a positive effect on bleeding control when used daily for 6 weeks.

Keyword

Cetylpyridinium; Dental plaque index; Prevention mouthrinse; Tranexamic acid

MeSH Terms

Adult
Cetylpyridinium*
Dental Plaque Index
Gingivitis*
Hemorrhage*
Humans
Mouth*
Periodontal Index
Tranexamic Acid*
Cetylpyridinium
Tranexamic Acid

Figure

• 

  Figure 1 Overview of the experimental protocol.QHI: Turesky-Quigley-Hein plaque index, GI: Löe-Silness gingival index, BOMP: bleeding on marginal probing.

• 

  Figure 2 The QHI. Statistically significant differences were evident after 3 weeks of treatment for both groups (experimental group: CPC and TXA, and placebo control group). At 6 weeks, a significant difference was observed in the intergroup analysis. There was a statistically significant difference in the values after 6 weeks of treatment for both groups. Bars represent mean±standard deviation.QHI: Turesky-Quigley-Hein plaque index, CPC: cetylpyridinium chloride, TXA: tranexamic acid.a)Statistically significant intragroup difference compared to the baseline, according to the Friedman test; b)Statistically significant intergroup difference between the 2 groups at 6 weeks, according to the Mann-Whitney U test.

• 

  Figure 3 The GI. A statistically significant difference was evident after 3 weeks of using the CPC and TXA mouthwash. Statistically significant differences were found between the values at baseline and those at 6 weeks for both groups. Bars represent mean±standard deviation.GI: Löe-Silness gingival index, CPC: cetylpyridinium chloride, TXA: tranexamic acid.a)Statistically significant intragroup difference compared to baseline, according to the Friedman test.

• 

  Figure 4 The incidence of gingival BOMP. In the CPC and TXA group, statistically significant differences were observed at 3 weeks and at 6 weeks.CPC: cetylpyridinium chloride, TXA: tranexamic acid, BOMP: bleeding on marginal probing. a)Statistically significant intragroup difference compared to baseline, according to the Friedman test.

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