Lab Anim Res.  2014 Dec;30(4):151-160. 10.5625/lar.2014.30.4.151.

Effects of pectin lyase-modified red ginseng extracts in high-fat diet-fed obese mice

Affiliations
  • 1Huvet Co., Ltd., Iksan, Korea.
  • 2Department of Oriental Pharmaceutical Development, Nambu University, Gwangju, Korea.
  • 3Korea Food Research Institute, Seungnam, Korea.
  • 4Center for Animal Resources Development, Wonkwang University, Iksan, Korea.
  • 5International Ginseng and Herb Research Institute, Geumsan, Korea. pmk67@ginherb.re.kr

Abstract

Red ginseng and its extracts have been used as traditional medicines and functional foods in countries worldwide. The aim of this study was to examine the bioavailability of pectin lyase-modified red ginseng extracts (GS-E3D), and the effects of GS-E3D on adipogenesis of 3T3-L1 adipocytes, as well as on metabolic disorders such as hyperglycemia, dyslipidemia, and fatty liver in high-fat diet fed obese C57BL/6 mice. Mice were divided into 5 groups: normal diet group, high fat diet-vehicle group, high fat diet + 0.1 g/kg GS-E3D (0.1-GS-E3D), high fat diet + 0.3 g/kg (0.3-GS-E3D), high fat diet + 1.0 g/kg (1.0-GS-E3D). Treatment of GS-E3D reduced differentiation of 3T3-L1 adipocytes with low cytotoxicity. In the animal model, compared to the high fat diet control, serum glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG, and leptin level were reduced in treatment animals in a dose-dependent manner. In addition, we found that GS-E3D could decrease total hepatic lipid droplets. These results suggest that GS-E3D, as a dietary supplement, has beneficial effects on obesity and may have useful effects in health-care products.

Keyword

High fat diet; red ginseng extract; hyperglycemia; dyslipidemia

MeSH Terms

Adipocytes
Adipogenesis
Animals
Biological Availability
Blood Glucose
Cholesterol
Diet
Diet, High-Fat
Dietary Supplements
Dyslipidemias
Fatty Liver
Functional Food
Hyperglycemia
Leptin
Mice
Mice, Obese*
Models, Animal
Obesity
Panax*
Cholesterol
Leptin
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