Korean J Pathol.  2000 Jul;34(7):524-530.

Tumor Angiogenesis and Vascular Endothelial Growth Factor Expression in Cervical Intraepithelial Neoplasia

• Park HJ
• Park HJ
• Moon HS
• Han WS
• Sung SH

Abstract

Angiogenesis is an essential requirement for development, progression, and metastasis of malignant tumors. Vascular endothelial growth factor (VEGF) is one of the important angiogenic factors. Recently the role of angiogenesis has been known in premalignant lesions. This study was performed to determine whether the angiogenesis and VEGF expression were increased in association with histological grade of cervical intraepithelial neoplasia (CIN) and to see the relationship between the angiogenesis and VEGF. Immunostainings for factor VIII and VEGF were performed on 52 cases of cervical neoplasia (12 cases of CIN I, 11 cases of CIN II, 15 cases of CIN III, 7 cases of microinvasive squamous cell carcinoma, and 7 cases of invasive carcinoma) and 5 cases of normal cervix. The results showed a significant increase of microvessel count from normal cervix through CIN grades to invasive squamous cell cacinoma. VEGF expression was increased in proportion to the CIN grades. There was no significant correlation between microvessel count and VEGF expression. In conclusion, the tumor angiogenesis is an early event in tumorigenesis of uterine cervix. In addition, no significant relationship between the microvessel count and VEGF expression in CIN suggests the possibility of other growth factors affecting mainly angiogenesis of premalignant lesion of uterine cervix.

Keyword

Angiogenesis; VEGF; Cervical intraepithelial neoplasia; Premalignant lesion

MeSH Terms

Angiogenesis Inducing Agents
Carcinogenesis
Carcinoma, Squamous Cell
Cervical Intraepithelial Neoplasia*
Cervix Uteri
Factor VIII
Female
Intercellular Signaling Peptides and Proteins
Microvessels
Neoplasm Metastasis
Vascular Endothelial Growth Factor A*
Angiogenesis Inducing Agents
Factor VIII
Intercellular Signaling Peptides and Proteins
Vascular Endothelial Growth Factor A