Korean J Pathol.  1999 May;33(5):337-346.

Histological Grading and Staging of Chronic Hepatitis Standardized Guideline Proposed by the Korean Study Group for the Pathology of Digestive Diseases

• Park YN
• Kim HG
• Chon CY
• Park JB
• Sohn JH
• Yang SH
• Yu ES
• Lee MS
• Jang JJ
• Chang HK
• Jeong JJ
• Kang DY
• Kim YI
• Park CI

Abstract

The terms chronic active hepatitis (CAH), chronic persistent hepatitis (CPH), and chronic lobular hepatitis (CLH) should be discontinued in favor of etiologic terminology. The activity of necro-inflammation and the degree of fibrosis should be evaluated for grading the severity and for the stage of disease. Members of the Korean Study Group for the Pathology of Digestive Diseases reviewed 30 cases of chronic hepatitis and reached the following consensus: 1) The pathology report of the biopsy samples with features of chronic hepatitis should include the etiology, grade and stage. 2) Grade and stage should be semiquantitatively evaluated as none, minimal, mild, moderate and severe. 3) For grading, lobular activity and periportal activity should be evaluated, separately. 4) To avoid confusion with other grading systems, simple report using descriptive terms rather than numerical records is recommended in daily practice. Criteria for each grade and stage should be presented and discussed. Histologic grading and staging of chronic hepatitis by new standardized guidelines will give more information about the prognosis as well as the present status of hepatitis. The terms CAH, CPH and CLH may be used in parentheses to facilitate relearning.

Keyword

Chronic hepatitis; Grade; Stage; Etiology

MeSH Terms

Biopsy
Consensus
Fibrosis
Hepatitis
Hepatitis, Chronic*
Pathology*
Prognosis