Korean J Hepatol.
2010 Sep;16(3):308-314. 10.3350/kjhep.2010.16.3.308.
Effect of alcohol on the development of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis: a cross-sectional case-control study
- Affiliations
-
- 1Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea. osshsjuj@yahoo.co.kr
- 2Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, Korea.
- 3Department of Internal Medicine, Inha University Hospital, Incheon, Korea.
- 4Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
- KMID: 1717326
- DOI: http://doi.org/10.3350/kjhep.2010.16.3.308
Abstract
- BACKGROUND/AIMS
Whether alcohol intake increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection remains controversial. The aim of this study was to determine the effect of alcohol intake on the development of HCC.
METHODS
Between January 2006 and August 2008, 146 patients with an initial diagnosis of HCC who were hospitalized in 3 major hospitals in the Incheon area were enrolled as cases. Another 146 cirrhotic patients, who matched the cases by age and sex, were enrolled as controls. All cases and controls were HBsAg positive, and had a history of lifetime alcohol intake.
RESULTS
The cases and controls were aged 53+/-8 and 53+/-9 years (mean+/-SD), respectively, with each group comprising 118 males and 28 females. The basal laboratory data, distribution of Child-Pugh class, HBeAg positivity (31.5% vs. 37.7%), HBV DNA level (5.74+/-2.35 vs. 5.98+/-2.29 log(10) copies/mL), and proportion with a lifetime alcohol intake of more than 292 kg (30.8% vs. 34.9%) did not differ between cases and controls. The cumulative alcohol intake and the proportion of heavy drinkers did not differ between the two groups in male patients.
CONCLUSIONS
Alcohol intake might not increase the risk of HCC in patients with HBV infection.
MeSH Terms
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Adult
Alcohol Drinking/*adverse effects
Carcinoma, Hepatocellular/epidemiology/*etiology
Case-Control Studies
Cross-Sectional Studies
DNA, Viral/blood
Female
Hepatitis B Surface Antigens/blood
Hepatitis B, Chronic/*complications
Humans
Liver Cirrhosis/*complications/epidemiology
Liver Neoplasms/epidemiology/*etiology
Male
Middle Aged
Risk Factors
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