Ewha Med J.  2014 Dec;37(Suppl):S33-S36. 10.12771/emj.2014.37.S.S33.

Hepatocellular Carcinoma Arising from Non-Cirrhotic Non-Alcoholic Steatohepatitis

  • 1Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea. ktydoc@hanyang.ac.kr
  • 2Department of Surgery, Hanyang University Guri Hospital, Guri, Korea.
  • 3Department of Pathology, Hanyang University Guri Hospital, Guri, Korea.


The major risk factors of hepatocellular carcinoma include hepatitis B or C virus infection and alcohol consumption in Korea which lead to liver cirrhosis development and progression. However, prevalence of non-alcoholic fatty liver disease related hepatocellular carcinoma is rising worldwide and hepatocellular carcinoma cases in patients with non-cirrhotic non-alcoholic steatohepatitis are increasing. A hypoechoic nodule was incidentally detected in a 52-year-old woman, with no evidence of liver cirrhosis or specific hepatocellular carcinoma findings on radiological examination. Non-cirrhotic non-alcoholic steatohepatitis-associated hepatocellular carcinoma was diagnosed based on clinical, laboratory, and histopathological findings of liver biopsy. To our knowledge, this is the first such case report in Korea.


Carcinoma, hepatocellular; Fatty liver; Non-alcoholic fatty liver disease
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