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Differing Associations between Fatty Liver and Dyslipidemia According to the Degree of Hepatic Steatosis in Korea

Han JM, Kim HI, Lee YJ, Lee JW, Kim KM, Bae JC

OBJECTIVE: Fatty liver is associated with insulin resistance-related diseases, such as dyslipidemia, obesity, and type 2 diabetes. The aim of this study was to evaluate the association of dyslipidemia with...
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Usefulness of Transient Elastography for Non-Invasive Diagnosis of Liver Fibrosis in Pediatric Non-Alcoholic Steatohepatitis

Kwon YD, Ko KO, Lim JW, Cheon EJ, Song YH, Yoon JM

BACKGROUND: Transient elastography (FibroScan®) is a non-invasive and rapid method for assessing liver fibrosis. While the feasibility and usefulness of FibroScan® have been proven in adults, few studies have focused...
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Hepatic failure caused by acute fatty liver of pregnancy treated by orthotopic liver transplantation: A case report

Bang YS, Ko D, Lee S, Lee S, Park C

Acute fatty liver of pregnancy (AFLP) is unusual but can potentially progress to overwhelming liver failure, resulting in maternal and fetal death. AFLP is characterized by the accumulation of microvesicular...
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Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases

Yi HS

The signaling network of the mitochondrial unfolded protein response (UPR(mt)) and mitohormesis is a retrograde signaling pathway through which mitochondria-to-nucleus communication occurs in organisms. Recently, it has been shown that...
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Tamoxifen-Induced Non-alcoholic Steatohepatitis Cirrhosis

Kim TH, Kim YB, Cheong JY, Cho SW, Kim SS

Non-alcoholic fatty liver disease has been observed in over 30% of patients who have received tamoxifen therapy. However, tamoxifen-induced non-alcoholic steatohepatitis (NASH) cirrhosis has never been reported in Korea. A...
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The role of hepatic macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Cha JY, Kim DH, Chun KH

Nonalcoholic steatohepatitis (NASH) is becoming common chronic liver disease because of the increasing global prevalence of obesity and consequently Nonalcoholic fatty liver disease (NAFLD). However, the mechanism for progression of...
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Protein and vitamin B6 intake are associated with liver steatosis assessed by transient elastography, especially in obese individuals

Ferro Y, Carè I, Mazza E, Provenzano F, Colica C, Torti C, Romeo S, Pujia A, Montalcini T

BACKGROUND/AIMS: Although the detrimental effects of several dietary components on the promotion of nonalcoholic fatty liver disease are well known, no studies have assessed the role of dietary vitamin B6....
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Comparative study of fatty liver induced by methionine and choline-deficiency in C57BL/6N mice originating from three different sources

Kim SH, Lim Y, Park JB, Kwak JH, Kim KJ, Kim JH, Song H, Cho JY, Hwang DY, Kim KS, Jung YS

Non-alcoholic fatty liver disease (NAFLD) is believed to be the most prevalent liver disease worldwide and a major cause of chronic liver injury. It is characterized by lipid accumulation in...
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Fatty liver associated with metabolic derangement in patients with chronic kidney disease: A controlled attenuation parameter study

Yoon CY, Lee M, Kim SU, Lim H, Chang TI, Kee YK, Han SG, Han IM, Kwon YE, Park KS, Lee MJ, Park JT, Han SH, Ahn SH, Kang SW, Yoo TH

BACKGROUND: Hepatic steatosis measured with controlled attenuation parameter (CAP) using transient elastography predicts metabolic syndrome in the general population. We investigated whether CAP predicted metabolic syndrome in chronic kidney disease...
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Maternal Death due to Acute Fatty Liver of Pregnancy

Kwon JH, Choi M, Ha H, Park S

Acute fatty liver of pregnancy (AFLP) is one of the sudden unexpected causes in pregnancy and maternal deaths. It has been considered as a potential fatal disease in pregnancy, but...
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Relationship between Serum 25-hydroxy-vitamin D Concentration and Risk of Metabolic Syndrome in Patients with Fatty Liver

Lim HS, Kim TH, Lee HH, Kim SK, Lee B, Park YH

BACKGROUND: The vitamin D deficiency rate in Koreans is still high and dietary intake is insufficient. The purpose of this study was to provide basic data for the management of...
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Comparative Study of Ultrasonography, Computed Tomography, Magnetic Resonance Imaging, and Magnetic Resonance Spectroscopy for the Diagnosis of Fatty Liver in a Rat Model

Noh H, Song XL, Heo SH, Kim JW, Shin SS, Ahn KY, Jeong YY, Kang HK

PURPOSE: To compare the accuracy of ultrasonography (US), single-energy CT (SECT), dual-energy CT (DECT), MR imaging (MRI), and MR spectroscopy (MRS) for detecting fatty liver in a rat model. MATERIALS AND...
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MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis

Chanda D, Li J, Oligschlaeger Y, Jeurissen , Houben T, Walenbergh SMA, Shiri-Sverdlov R, Neumann D

Non-alcoholic steatohepatitis (NASH), a metabolic disorder consisting of steatosis and inflammation, is considered the hepatic equivalent of metabolic syndrome and can result in irreversible liver damage. Macrophage-stimulating protein (MSP) is...
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Can Pharmacologic Therapy Induce Histologic Improvement in Non-alcoholic Steatohepatitis?

Heo NY

No abstract available.
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Diagnostic value of alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index combined with γ-glutamyl transferase in differentiating ALD and NAFLD

Wang J, Li P, Jiang Z, Yang Q, Mi Y, Liu Y, Shi R, Zhou Y, Wang J, Lu W, Li S, Liu D

BACKGROUND/AIMS: This study aimed to verify the reliability of the alcoholic liver disease (ALD)/nonalcoholic fatty liver disease (NAFLD) index (ANI) for distinguishing ALD in patients with hepatic steatosis from NAFLD,...
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Waist-to-Height Ratio as a Simple and Useful Indicator for Non-alcoholic Fatty Liver Disease in Korean Women

Lim HJ, Seo MS, Lee HR, Shim JY, Kang HT, Lee YJ

BACKGROUND: It has not been determined which obesity index might be most appropriate to predict nonalcoholic fatty liver disease in Asian populations. This study aimed to evaluate the usefulness of...
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The Relationship between 10-Year Cardiovascular Risk Calculated Using the Pooled Cohort Equation and the Severity of Non-Alcoholic Fatty Liver Disease

Lee JI, Kim MC, Moon BS, Song YS, Han EN, Lee HS, Son Y, Kim J, Han EJ, Park HJ, Park SE, Park CY, Lee WY, Oh KW, Park SW, Rhee EJ

BACKGROUND: We investigated the association between the severity of non-alcoholic fatty liver disease (NAFLD) and the estimated 10-year risk of cardiovascular disease (CVD) calculated by Pooled Cohort Equation (PCE) and...
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Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis

Povero D, Feldstein

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it...
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Protective Effects of Ecklonia stolonifera Extract on Ethanol-Induced Fatty Liver in Rats

Bang CY, Byun JH, Choi HK, Choi JS, Choung SY

Chronic alcohol consumption causes alcoholic liver disease, which is associated with the initiation of dysregulated lipid metabolism. Recent evidences suggest that dysregulated cholesterol metabolism plays an important role in the...
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Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice

Park HS, Jang JE, Ko MS, Woo SH, Kim BJ, Kim HS, Park HS, Park IS, Koh EH, Lee KU

BACKGROUND: Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes...
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