Korean J Dermatol.
1980 Aug;18(4):281-286.
Alternating Topical Treatment with Perinoic Acid And Retinoid (Ro 11 - 1430) on Acne Vulgaris: therapeutic effect and side reactions
Abstract
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The retinoic acid and retinoid(Ro 11-1430) were alternately applied topically on forty patients with acne vulgaris. Therapeutic effects and side reactions of this regimen were compared with our previous studies of the treatment with retinoic acid alone and with retinoid alone. Compared with the treatment with retinoic acid alone, the therapsutic effect of the alternating treatment was relatively superior as indicated by the markedly reduced severity of local side reactions.