Korean J Dermatol.  1978 Feb;16(1):41-47.

A Clinical Study for Topical Vitamin A Acid Derivative in Acne Vulgaris

• Kim EJ
• Shin S

Abstract

Many modalities for the treatment of acne vulgaris have been introduced, but the results of the treatment were variable and unsatisfactory. In 1969, Kligman ct al reported that vitamin A acid was one of the mot effective raembers of the topical therapeutics for ance than any other topical remedies. But the undesirable side effects of vitamin A acid limit its use, and so we us instead of vitamin A acid for minimizing of possible side effects The results are as follows: 1. The total number of skin eruption progressively diminished after treatment with topical vitamin A acid derivatives and we found significant diminution on fourth week, and the effectiveness of the total patients was 73.7%. 2. The number of papules and closed comedories progressively diminished after treatment, but that of open corzelones slightly increased on first week of the treatment and diminished thereafter. 3. The number of pustules too few to evaluate with statistical analysis, but newly developed pustules noted speciaelly in first and second weeks wit.h unpredictable courses 4. The frequent, undesirable side effects were scale, buming & stinging and erythemas in order of frequeny, but other side effeccs auch as itching, tightness, pain, and pigmentation also noted in a few patients but the side effect.s were mild. So we considered the effectiveness of vitamin A acid derivatives were as good as those of vit,amin A acid, but the undesirable side effects of vitamin A acid. derivatives were less severe than those of vitamin A acirl.

MeSH Terms

Acne Vulgaris*
Bites and Stings
Erythema
Humans
Pigmentation
Pruritus
Skin
Tretinoin*
Vitamin A*
Vitamins*
Tretinoin
Vitamin A
Vitamins