Korean Circ J.  1989 Mar;19(1):117-124. 10.4070/kcj.1989.19.1.117.

Hypotensive Effect of Guanabenz Acetate(Rexitene(R))in Essential Hypertension;A Clinical Study

• Jeong JW
• Park YK
• Park OK
• Park JC
• Jeong MH
• Cho JG
• Kang JC

• KMID: 1670380
• DOI: http://doi.org/10.4070/kcj.1989.19.1.117

Abstract

To evaluate the hypertensive effect of guanbenz acetate, we performed a prospective clinical study for 10 weeks or more in 27 patients with essential hypertension(mean age: 51, mean supine blood pressure: 176/105mmHg). The daily dose of guanabenz acetate was 8-49 mg. The results were as follows; 1) After 2, 4, 6 and 8 weeks of treatment, average supine systolic and diastolic blood pressures reduced to 156/94, 150/94, 149/93 and 144/93mmHg respectively(all P<0.05). 2) Pulse rate decreased slightly from pre-treatment average of 75 beats per minute to 71 beats per minute at the end of the study(P<0.05). 3) Average body weight, serum levels of total cholesterol, AST, ALT, BUN, creatinine, sodium and potassium were not significantly changed from pre-treatment values. 4) A few side effects in order of frequency were dry mouth, dizziness, sedation, weakness, etc. We conclude that guanabenz acetate may be used as an effective first line antihypertensive agent in essential hypertension.

Keyword

Guanabenz acetate; Essential hypertension

MeSH Terms

Blood Pressure
Body Weight
Cholesterol
Creatinine
Dizziness
Guanabenz*
Heart Rate
Humans
Hypertension
Mouth
Potassium
Prospective Studies
Sodium
Cholesterol
Creatinine
Guanabenz
Potassium
Sodium