Korean Circ J.  1984 Dec;14(2):373-376. 10.4070/kcj.1984.14.2.373.

Clinical Trial on the Hypotensive Effect of Buterazine

• Kwon MS
• Oh SC
• Park MS
• Lim HK
• Lee BH
• Lee CK

• KMID: 2093202
• DOI: http://doi.org/10.4070/kcj.1984.14.2.373

Abstract

The hypotensive effect and side reactions of Buterazine were evaluated in 21 patients with essential hypertension. The results were as follows; 1) Before medication and after 2 and 4 weeks of medication, the over all average systolic and diastolic pressure were 188+/-23/112+/-7, 168+/-13/101+/-17, and 158+/-12/95+/-8mmHg, respectively. After 2 and 4 weeks of medication, the over all average systolic pressure decreased by 20 and 30mmHg(P<0.005, P<0.001), and the over all average diastolic pressure decreased by 11 and 17mmHg(P<0.025, P<0.001), respectively. In 69% of all cases, marked or moderate degree of hypotensive effect was observed. 2) There was no significant changes in heart rates before and after treatment. 3) In 84% of all cases, improvement of symptoms were observed. 4) There was no side effects which required discontinuing the treatment, except 2 cases which discontinued the medication.

MeSH Terms

Blood Pressure
Heart Rate
Humans
Hypertension