Korean J Pediatr.  2004 Nov;47(11):1205-1209.

Urine Organic Acid Analysis of Patients with Febrile Seizures

• Shin DS
• Lee GJ
• Lee KJ
• Park WI
• Bae EJ
• Lee HG

Abstract

PURPOSE
Febrile seizure, the most common seizure disorder in children between 6 months and 5 years of age, is mostly caused by viral infections, except severe CNS infection. It can also be caused by disorders in organic acid metabolism, especially accompanied by fever. Therefore we decided to investigate the relationship between children with febrile seizures and disorders in organic acid metabolism.
METHODS
We examined 54 children with febrile seizure who visited Chunchon Sacred Heart Hospital Emergency Department from February 2002 to January 2004. We conducted urine organic acid analysis, CBC, urine analysis, serum ammonia and gas analysis.
RESULTS
Thirteen(24.1%) patients showed ketonuria, eight(14.8%) patients showed lactic aciduria and ketonuria, two(3.7%) patients showed pyruvic aciduria, and one(1.8%) showed mandelic aciduria.
CONCLUSION
Twenty four of 54(44.4%) showed abnormal findings in urine organic acid analysis. Most results are ketonuria or lactic aciduria with ketonuria. They may show in fasting, severe infection or ketolytic defect(ex, 3-ketothiolase deficiency). Patients with 3-ketothiolase deficiency, can develop seizures during fever, and fasting state. Therefore further evaluation is necessary.

Keyword

Seizures; Febrile; Acetyl CoA C-Acytransferase; Amino acid metabolism; Inborn errors; Lactic acid

MeSH Terms

Acetyl-CoA C-Acyltransferase
Ammonia
Child
Emergency Service, Hospital
Epilepsy
Fasting
Fever
Gangwon-do
Heart
Humans
Ketosis
Lactic Acid
Metabolism
Seizures
Seizures, Febrile*
Acetyl-CoA C-Acyltransferase
Ammonia
Lactic Acid