Korean J Dermatol.  2003 Mar;41(3):367-370.

A Case of Generalized Pustular Psoriasis Associated with Myasthenia Gravis

• Ryu JH
• Jeon HJ
• Bang HD
• Kim KH
• Kim KJ

Abstract

Generalized pustular psoriasis(GPP) is an uncommon and severe form of psoriasis. The possible provocative factors such as steroid therapy, infection, stress, drugs, pregnancy, sun exposure, and metabolic disorders were reported. Among them, corticosteroid therapy is thought to be the most common factor. Although the cause of psoriasis remain obscure, the coexistence of psoriasis and autoimmune disease and cyclosporin accepted for the treament of psoriasis emphasize the importance of immunologic mechanism in the pathogenesis of psoriasis. We present a case of GPP in a 48-year-old male, who has had a history of myasthenia gravis since the age of 34 years and managed with long-term corticosteroid therapy. With the administration of acitretin and cyclosporin, generalized pustular eruptions nearly cleared and clinical improvement was achieved.

Keyword

Generalized pustular psoriasis; Myasthenia gravis

MeSH Terms

Acitretin
Autoimmune Diseases
Cyclosporine
Humans
Male
Middle Aged
Myasthenia Gravis*
Pregnancy
Psoriasis*
Solar System
Acitretin
Cyclosporine