J Asthma Allergy Clin Immunol.  2003 Mar;23(1):95-98.

A case of angioedema associated with losartan

• Kim MC
• Kim JS
• Chung JW
• Song HJ
• Choi JH
• Suh YJ
• Suh CH
• Nahm DH
• Park HS

Abstract

Angioedema is a non-pitting edema that occurs in the skin and mucus membranes. It is known that major etiologies include hereditary deficiency of C1 esterase inhibitor, temperature extreme, trauma, food sensitivity, and medications such as penicillin, aspirin, NSAIDS and ACE inhibitors. ACE inhibitors are blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and increasing local levels of bradykinin, a potent vasodilator. This increased bradykinin has been theorized to cause angioedema and cough in patients on ACE inhibitors. However, there has been very few causes of angioedema induced by angiotensin II receptor blocker. This is the first report of a patient presenting angioedema induced by losartan -angiotensin II receptor blocker- in this century.

Keyword

Angioedema; angiotensin II receptor blocker

MeSH Terms

Angioedema*
Angiotensin I
Angiotensin II
Angiotensin-Converting Enzyme Inhibitors
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Bradykinin
Cough
Edema
Hereditary Angioedema Types I and II
Humans
Losartan*
Membranes
Mucus
Penicillins
Receptors, Angiotensin
Skin
Angiotensin I
Angiotensin II
Angiotensin-Converting Enzyme Inhibitors
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Bradykinin
Losartan
Penicillins
Receptors, Angiotensin