Korean J Physiol Pharmacol.
2004 Aug;8(4):173-179.
The Role of BF-7 on Neuroprotection and Enhancement of Cognitive Function
- Affiliations
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- 1Department of Anatomy, College of Medicine, Chung-Ang University, Seoul, Korea. sungsu@cau.ac.kr
- 2Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Korea.
- 3Department of Thoracic & Cardiovascular Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.
- 4Department of Biogrand Inc., Chung-Ang University, Seoul, Korea.
- 5Department of Pharmacology, Seoul Municipal Boramae Hospital, College of Medicine, Seoul National University, Seoul, Korea.
- 6Department of Neurosurgery, Seoul Municipal Boramae Hospital, College of Medicine, Seoul National University, Seoul, Korea.
- 7Department of Sericultural and Entomology, National Institute of Agriculture Science Technology, RDA, Suwon, Korea.
Abstract
- Amyloid beta-peptide (A beta) contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against A beta -induced toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated A beta-induced apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.
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