Korean J Physiol Pharmacol.
2004 Dec;8(6):307-312.
The Improvement of Learning and Memory Ability of Normal Persons by BF-7
- Affiliations
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- 1Department of Neurosurgery, College of Medicine, Seoul National University, Korea.
- 2Department of Pharmacology, College of Medicine, Seoul National University, Korea.
- 3Department of Anatomy, College of Medicine, Chung-Ang University, Seoul, Korea.
- 4Department of Neurology, College of Medicine, Chung-Ang University, Seoul, Korea.
- 5Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Korea.
- 6Department of Physiology, College of Medicine, Chung-Ang University, Seoul, Korea.
- 7Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea. taejlee@chollian.net
- 8Applied Entomology Division, Department of Sericulture and Entomology, National Institute of Agriculture Science Technology, Suwon, Korea.
Abstract
- To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-7 plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.
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