Korean J Otolaryngol-Head Neck Surg.  2006 Dec;49(12):1165-1171.

The Effect of Genotype of NAT2, TNF-alpha and TGF-beta Genes on Allergic Rhinitis in Korea

• Park YK
• Kang JW
• Kim YD
• Lee CH
• Eom SY
• Kim H

Abstract

BACKGROUND AND OBJECTIVES
The inflammatory reaction is affected by the genotype or phenotype of genes related with inflammation modulating cytokines and allergen metabolizing enzyme. This study was performed to investigate the relationship between N-acetyl transferase 2 (NAT2), tumor necrosis factor-alpha(TNF-alpha), transforming growth factor-beta(TGF-beta) and the allergic rhinitis in Korea.
SUBJECTS AND METHOD
One hundred forty five allergic rhinitis patients and 167 controls were included. Venous blood samples were collected and the genotypes were analyzed by PCR technique. NAT2 phenotypes were designated as 'high', 'medium' and 'low' by known genotype-phenotype relationship. TNF-alpha genotypes were classified as 'A/A', 'A/G' and 'G/G'. TGF-beta genotype was classified as 'Arg/Arg', 'Arg/Pro' and 'Pro/Pro'. These data were analyzed by SAS for windows ver 8.02.
RESULTS
The phenotype of NAT2 and genotype of TGF-beta showed no significant effect on allergic rhinitis. G/G or G/A genotype of TNF-alpha significantly increases the risk of allergic rhinitis. High activity phenotype of NAT2 showed higher level of total serum IgE.
CONCLUSION
Genetic factors including TGF-beta are important in the development of allergic rhinitis in Korea. NAT2 phenotype affect allergic reaction.

Keyword

Allergic rhinitis; NAT2; TNF-alpha; TGF-beta

MeSH Terms

Cytokines
Genotype*
Humans
Hypersensitivity
Immunoglobulin E
Inflammation
Korea*
Necrosis
Phenotype
Polymerase Chain Reaction
Rhinitis*
Transferases
Transforming Growth Factor beta*
Tumor Necrosis Factor-alpha*
Cytokines
Immunoglobulin E
Transferases
Transforming Growth Factor beta
Tumor Necrosis Factor-alpha