J Korean Rheum Assoc.
2006 Jun;13(2):150-154.
A Case of Avascular Necrosis of Mandible Associated with the Use of Bisphosphonate in a Patient with Rheumatoid Arthritis and Osteoporosis
- Affiliations
-
- 1Department of Internal Medicine, The Catholic University of Korea Medical College, Holy Family Hospital, Bucheon, Korea. rmin6403@hanmail.net
- 2Department of Dentistry, The Catholic University of Korea Medical College, Holy Family Hospital, Bucheon, Korea.
- 3Department of Pathology, The Catholic University of Korea Medical College, Holy Family Hospital, Bucheon, Korea.
Abstract
- Bisphosphonates decrease osteoclastic activity and reduce bone resorption, therefore they are used in the treatment of patients with hypercalcemia secondary to malignancy or metastatic bone cancer, Paget's disease and osteoporosis. Recently, cases of jaw bone necrosis have been reported to be associated with the use of bisphosphonates. In patients with rheumatoid arthritis, osteoporosis is frequently developed because of osteoclast activation and steroids which are used for treatment and bisphosphonates are frequently prescribed. A 76-year-old female patient with rheumatoid arthritis was treated with alendronate for the management of osteoporosis for 36 months, and she was presented with pain and swelling on left mandibular area and gingival pus discharge. The patient was treated with curettage of necrotic bone, and biopsy showed avascular necrosis of mandible.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Insufficiency Fracture of Proximal Femur Shaft without Bisphosphonate Therapy: Report of Three Cases
- Oral Bisphosphonate Related Osteonecrosis of the Jaws: A case report
- Clinical characteristics of osteoporosis in patients with rheumatoid arthritis: Disease activity matters
- Reconstruction of Defect after Treatment of Bisphosphonate-related Osteonecrois of the Jaw with Staged Iliac Bone Graft
- Bisphosphonate: An Invaluable Medication or Abandoned Acid?
