Cancer Res Treat.
2002 Dec;34(6):436-438.
l-myc Polymorphism in Gastric Cancer, Lung Cancer, and Hepatocellular Carcinoma
- Affiliations
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- 1Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Korea. jhchung@ khu.ac.kr
- 2Division of Medical Oncology, Korea Cancer Center Hospital, Korea.
- 3Division of Medical Oncology, Seoul Veterans Hospital, Seoul, Korea.
- 4Division of Gastroenterology, College of Medicine, Hallym University, Pyungchon, Korea.
Abstract
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PURPOSE: This study was performed to see if a particular polymorphism in the l-myc, a nuclear oncogene at the 1p32 locus, might be associated with greater risk of gastric cancer, lung cancer and hepatocellular carcinomas (HCC) in Korean patients.
MATERIALS AND METHODS
Genomic DNA, derived from patients diagnosed with gastric cancer (n=57), lung cancer (n=39), HCC (n=35) and healthy individuals (n= 176), was examined. The l-myc polymorphism under study was visualized by PCR followed by EcoRI digestion.
RESULTS
There was no significant difference in the distribution of the l-myc polymorphism genotypes and allele frequencies between the cancer patients and the controls.
CONCLUSION
The l-myc polymorphism does not appear to be indicative of elevated risk of cancers of the stomach, lung and HCC.
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