Korean J Immunol.  1997 Jun;19(2):245-262.

Apoptosis of Fas Expressed Target Cells Induced by Cytotoxic T Lymphocytes

• Kim SH
• Kim SY

Abstract

Cytotoxic T lymphocytes (CTL) playing an important role in e cell-mediated immune response kill the target cells by the special contact-dependent mechanism. It has been known that CTL and NK cells utilize two different pathways in removing specific target cells: apoptotic cell death and osmotic lysis by the pore forming protein. Interaction of CTL with target cells results in the ligand-induced, receptor-mediated, nonsecretory lytic process and lethal hit is delivered by the transducing molecule, Fas (CD95, APO-1), one of the TNFR/NGFR superfamily. In addition, ligation of TNF receptor and CD40 also induced the apoptosis of B cell and epithelial cells. However, recognition of target cells, the triggering mechanism, cytotoxic mediators, internal metabolic pathway and signal transduction behind apoptosis remain undefined and have been elucidated only in part. ...continue...

Keyword

CTL; Fas; FasL; Genistein; ICE; Apoptosis

MeSH Terms

Apoptosis*
Cell Death
Epithelial Cells
Genistein
Ice
Killer Cells, Natural
Ligation
Metabolic Networks and Pathways
Receptors, Tumor Necrosis Factor
Signal Transduction
T-Lymphocytes, Cytotoxic*
Genistein
Ice
Receptors, Tumor Necrosis Factor