Infect Chemother.
2007 Oct;39(5):259-262.
A Case of Good's Syndrome
- Affiliations
-
- 1Department of Internal Medicine, Seoul National University College of Medicine, Korea. hbkimmd@snu.ac.kr
- 2Department of Laboratory Medicine, Seoul National University College of Medicine, Korea.
- 3Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Korea.
Abstract
- Good's syndrome is the association of thymoma with immunodeficiency, characterized by hypogammaglobulinemia, B-cell lymphopenia and variably defects in cellular immunity with CD4+ T-cell lymphopenia and an inverted CD4+:CD8+ T-cell ratio. We report a 43-year-old male patient who presented with a 18-month history of productive cough and postnasal drip. One year ago, he underwent the operation for resection of a thymoma. Despite of appropriate management, sinusitis relapsed multiple times. He was found to have hypogammaglobulinemia with nearly absent B cells(4/microliter). The CD4+ T-cell count was 554/microliter with an inverted CD4+:CD8+ T-cell ratio of 0.6. His symptoms and signs improved with antibiotic treatment and monthly administration of intravenous immunoglobulin (IVIG, 400 mg/kg).
