Hanyang Med Rev.  2007 Aug;27(3):34-40.

Pathogenesis of Helicobacter pylori-induced Gastric Cell Injury

• Park SW
• Hahm KB

Abstract

H. pylori infection has been revealed to cause chronic gastric inflammation, which may progress to gastric ulcers and duodenal ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma as well as gastric adenocarcinoma. The mechanisms by which bacterial infection leads to gastric mucosal damage include the direct effects of virulence factors produced by H. pylori, such as cagA, vacA or urease, the propagation and perpetuation of inflammation, oxidative stress, and the induction of apoptosis in infected gastric epithelial cells. In the current review, the pathogenic mechanisms with their clinical relevance will be described.

Keyword

Helicobacter pylori; Gastric Cell Injury; Pathogenesis

MeSH Terms

Adenocarcinoma
Apoptosis
Bacterial Infections
Duodenal Ulcer
Epithelial Cells
Helicobacter pylori
Helicobacter*
Inflammation
Lymphoid Tissue
Lymphoma
Oxidative Stress
Stomach Ulcer
Urease
Virulence Factors
Urease
Virulence Factors