Korean J Helicobacter Up Gastrointest Res.  2016 Sep;16(3):134-138. 10.7704/kjhugr.2016.16.3.134.

Vaccine Development and Future for Helicobacter pylori

• Cho SJ

• KMID: 2351889
• DOI: http://doi.org/10.7704/kjhugr.2016.16.3.134

Abstract

Helicobacter pylori is one of the most common gastric pathogens, affecting at least half the world's population, and is strongly associated with gastritis, peptic ulcer, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Vaccination against H. pylori has been challenging because of its low efficacy, lack of information about protective immunity, and disappointing clinical studies. A recent phase 3 clinical trial in China was reported to be successful to test prophylactic vaccination against H. pylori, which caused growing interest in the vaccine development against H. pylori. Here, we review literatures regarding vaccination against H. pylori.

Keyword

Helicobacter pylori; Vaccine

MeSH Terms

Adenocarcinoma
China
Gastritis
Helicobacter pylori*
Helicobacter*
Lymphoma, B-Cell, Marginal Zone
Peptic Ulcer
Vaccination