J Korean Soc Pediatr Endocrinol.
2006 Jun;11(1):28-32.
The Relationship between Insulin-like Growth Factor Binding Protein-3 Promoter Polymorphism and Growth
- Affiliations
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- 1Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea.
- 2Liver cell signal transduction Lab., Korea Research Institute of Bioscience and Biotechnology, Daejon, Korea.
- 3Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. hjshin@hanyang.ac.kr
Abstract
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PURPOSE: The variability in insulin-like growth factor binding protein-3 (IGFBP-3) levels is related to polymorphic variants of the promoter region of the gene. The most common single nucleotide polymorphism of IGFBP promoter region is -202 locus. In vitro, significantly higher promoter activity of the A allele at the -202 locus compared with the C allele, consistent with the relationship observed between genotype and circulating IGFBP-3 was documented. The polymorphic variation occurs frequently and may influence GH responsiveness, somatic growth, but the effects of IGFBP-3 promoter polymorphism on growth in children are unknown.
METHODS
RFLP genotyping of the -202 single nucleotide polymorphism was performed in 33 Korean children who visited our clinic for evaluation of their growth. The serum levels of IGF-I and IGFBP-3 were compared according to genotyping.
RESULTS
Height SDS of subjects was -1.48+/-1.10. 11 of 33 children (33%) were heterozygous AC and the others are homozygous AA in genetic distribution, but no homozygous CC was detected. C allele frequency was 16.7%. There were no significant differences in height, body mass index, serum IGF-I and IGFBP-3 levels between AC and AA groups.
CONCLUSION
The effects of IGFBP-3 promoter polymorphism on growth at the -202 locus deserve investigation because there is no CC and the children were relatively short in this study.
Keyword
MeSH Terms
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Alleles
Body Height
Child
Gene Frequency
Genotype
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
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