Korean J Anat.  2006 Dec;39(6):515-522.

Analysis of Chromosomal Aberrations in Head and Neck Squamous Cell Carcinoma Cell Lines using CGH

• Park SY

Abstract

The knowledge about chromosomal aberrations manifestated in cancer has been spotlighted recently, and these studies are important for the development of cancer diagnosis and evaluation of prognosis. Purpose of this study was examine the chromosomal aberrations which were related in the development and progression of HNSCC. In this study, chromosomal aberrationsin HNSCC cell line, SNU-1041, SNU-1066, SNU-1076, PCI-1, PCI-13, and PCI-50 were analyzed using CGH. As a results, gains on 9q32-q34, 16q22-q24, and 20q11.2-qter were observed in all six cell lines. Loss on 3p10-p14 was analyzed in five cell lines. Also, losses on 3p15-p23, 4q22-q27, 4q31.3-qter, and 18q21-q23 were observed in four cell lines. These data about the patterns of chromosomal aberrations in HNSCC cell lines would be a basic step for understanding more detailed genetic events in the carcinogenesis.

Keyword

CGH; HNSCC; Chromosome; Aberration

MeSH Terms

Carcinogenesis
Carcinoma, Squamous Cell*
Cell Line*
Chromosome Aberrations*
Diagnosis
Head*
Neck*
Prognosis