Immune Netw.  2014 Feb;14(1):1-6. 10.4110/in.2014.14.1.1.

Reproduction of Epstein-Barr Virus Infection and Pathogenesis in Humanized Mice

• Fujiwara S

• KMID: 1508822
• DOI: http://doi.org/10.4110/in.2014.14.1.1

Abstract

Epstein-Barr virus (EBV) is etiologically associated with a variety of diseases including lymphoproliferative diseases, lymphomas, carcinomas, and autoimmune diseases. Humans are the only natural host of EBV and limited species of new-world monkeys can be infected with the virus in experimental conditions. Small animal models of EBV infection, required for evaluation of novel therapies and vaccines for EBV-associated diseases, have not been available. Recently the development of severely immunodeficient mouse strains enabled production of humanized mice in which human immune system components are reconstituted and express their normal functions. Humanized mice can serve as infection models for human-specific viruses such as EBV that target cells of the immune system. This review summarizes recent studies by the author's group addressing reproduction of EBV infection and pathogenesis in humanized mice.

Keyword

Epstein-Barr virus; Humanized mouse; Lymphoproliferative disease; Rheumatoid arthritis; Immune response; Persistent infection

MeSH Terms

Animals
Arthritis, Rheumatoid
Autoimmune Diseases
Epstein-Barr Virus Infections
Haplorhini
Herpesvirus 4, Human*
Humans*
Immune System
Lymphoma
Mice*
Models, Animal
Reproduction*
Vaccines
Viruses
Vaccines