J Korean Surg Soc.  2013 Jun;84(6):321-329. 10.4174/jkss.2013.84.6.321.

Antiadhesive effect and safety of oxidized regenerated cellulose after thyroidectomy: a prospective, randomized controlled study

Affiliations
  • 1Department of Surgery, Konkuk University School of Medicine, Seoul, Korea.
  • 2Division of Endocrine Surgery, Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. ykyoun@plaza.snu.ac.kr
  • 3Department of Surgery, Kyung Hee University School of Medicine, Seoul, Korea.
  • 4Department of Surgery, Korea University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
To evaluate the antiadhesive effects and safety of an oxidized regenerated cellulose (Interceed) after thyroidectomy.
METHODS
Seventy-six thyroidectomized patients were prospectively randomized into two groups with regard to the use of Interceed. We evaluated each group for their adhesive symptoms using four subjective and four objective items at the 2nd week, 3rd and 6th month after thyroidectomy. All patients were examined for vocal cord motility by indirect laryngoscope at each period.
RESULTS
Total adhesion scores at each postoperative follow-up period decreased with time, but were not significantly different in each group. The median score for swallowing discomfort for liquid was significantly lower in the Interceed group than in the control group 2 weeks after surgery. In addition, the severity of skin adhesion to the trachea was reduced in the Interceed group compared with the control group 6 months after surgery. During the study, there were no adverse effects or significant differences in postoperative complications between the groups.
CONCLUSION
Interceed appeared to be safe and effective in improving neck discomfort at early postoperative periods and preventing skin adhesion to the trachea 6 months after thyroidectomy.

Keyword

Adhesion; Neck discomfort; Oxidized regenerated cellulose; Thyroidectomy

MeSH Terms

Adhesives
Cellulose
Cellulose, Oxidized
Deglutition
Follow-Up Studies
Humans
Laryngoscopes
Neck
Postoperative Complications
Postoperative Period
Prospective Studies
Skin
Thyroidectomy
Trachea
Vocal Cords
Adhesives
Cellulose
Cellulose, Oxidized
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