Arch Craniofac Surg.  2019 Oct;20(5):289-296. 10.7181/acfs.2019.00472.

Wound healing effect of regenerated oxidized cellulose versus fibrin sealant patch: An in vivo study

Affiliations
  • 1Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Iksan, Korea. ycnadr@hanmail.net
  • 2Department of Pathology, Wonkwang University Hospital, Iksan, Korea.

Abstract

BACKGROUND
Topical hemostatic agents are used when ligation, electrocauterization, or other conventional hemostatic methods are impractical. Because a hemostatic agent is a foreign body, it can cause foreign body reactions, inflammation, and infections that can interfere with the wound healing process. Therefore, we should select hemostatic agents after considering their effects on wound healing. Here, we compared the effects of hemostatic agents on wound healing in a rectus abdominis muscle defect in rats.
METHODS
Twelve Sprague Dawley rats were subjected to creation of a 6 × 6 mm defect in the rectus abdominis muscle and divided into four groups: control group; group A, Tachosil fibrin sealant patch; group B, Surgicel Fibrillar oxidized regenerated cellulose; and group C, Surgicel Snow oxidized regenerated cellulose. For the histologic analysis, biopsies were performed on the 3rd, 7th, and 27th days.
RESULTS
The foreign body reaction was the weakest in group A and most significant in group C. The inflammatory cell infiltration was the weakest in group A and similar in groups B and C. Muscle regeneration differed among periods. The rats in group A were the most active initially, while those in group C showed prolonged activity.
CONCLUSION
Tachosil and Surgicel administration increased inflammation via foreign body reactions, but the overall wound healing process was not significantly affected. The increased inflammation in the Surgicel groups was due to a low pH. We recommend using Tachosil, because it results in less intense foreign body reactions than Surgicel and faster wound healing due to the fibrin action.

Keyword

Cellulose; Fibrin; Fibrinogen; Hemostatics; Thrombin; Wound healing

MeSH Terms

Animals
Biopsy
Cellulose
Cellulose, Oxidized*
Fibrin Tissue Adhesive*
Fibrin*
Fibrinogen
Foreign Bodies
Foreign-Body Reaction
Hemostatics
Hydrogen-Ion Concentration
Inflammation
Ligation
Rats
Rats, Sprague-Dawley
Rectus Abdominis
Regeneration
Snow
Thrombin
Wound Healing*
Wounds and Injuries*
Cellulose
Cellulose, Oxidized
Fibrin
Fibrin Tissue Adhesive
Fibrinogen
Hemostatics
Thrombin
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